Antibacterial drugs used in the Breastfeeding, Antiretrovirals and Nutrition study, Malawi, 2004-2010 Class Drug Aminoqlycoside Gentamicin Cephalosporins Ceftriaxone Cefuroxime Loracarbef
Nitroimidazole Metronidazole Penicillins Amoxicillin Ampicillin Augmentin Benzathine penicillin Benzylpenicillin Cloxacillin Flucloxacillin [beta]-lactams/[beta]-lactamase inhibitor Amoxicillin/clavulanate combination Phenicols Chloramphenicol Quinolones Ciprofloxacin Nalidixic acid Sulfonamides Cotrimoxazole Sulfadiazine Tetracyclines/macrolides Doxycycline Erythromycin Tetracycline Table 2.
 Cefaclor, cefixime and loracarbef
are less active in vitro against S.
cancerogenus has a natural resistance to amoxicillin, amoxicillin/clavulanic acid, cefazolin, cefaclor, cefazoline, loracarbef
, and cefloxitin.
All pneumococcal isolates (excluding meningitis) with a penicillin MIC of [less than or equal to]0.06 [micro]g/ml can be considered susceptible to amoxicillin, amoxicillin-clavulanic acid, cefaclor, loracarbef
, cefprozil, cefuroxime and cefpodoxime for approved indications.
Antimicrobial drug suspensions: a blinded comparison of taste of twelve common pediatric drugs including cefixime, cefpodoxime, cefprozil and loracarbef
. Pediatr Infect Dis J.
(Combined with high-dose amoxicillin, however, such a combination would be expected to work very well.) Also not listed are cefaclor and loracarbef
because their efficacy, by current standards, has not been tested and they are anticipated not to be that good, although the tolerability is excellent.
 Amoxicillin 01 Amoxicillin and Clavulanic Acid (Augmentin) 02 Azithromycin (Zithromax) 03 Cafaclor (Ceclor) 04 Cefixime (Suprax) 05 Cefpodoxime (Vantin) 06 Cefprozil (Cefzil) 07 Cetriaxone (Rocephin) 08 Clarithromycin (Biaxin) 09 Erythromycin and Sulfisoxazone (Pediazole) 10 Loracarbef
(Lorabid) 11 Trimethoprim and Sulfamethoxazole (Bactrim, Septra) 12 Other 13 No Data 99
Other effective agents include clarithromycin, cefprozil, loracarbef
, and amoxicillin and clavulanic acid.
([double dagger]) Per 10% increase in cephalosporin prescribing during the previous year; includes cefaclor, cefadroxil, cefdinir, cefditoren pivoxil, cefixime, cefpodoxime proxetil, cefprozil, ceftibuten, cefuroxime axetil, cephalexin, cephradine, and loracarbef
. ([section]) Per 10% increase in fluoroquinolone prescribing during the previous year; includes ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, and trovafloxacin.
In Enterobacter cancerogenus, resistance to amoxicillin, amoxicillin/clavulanic acid, cefazolin, cefaclor, cefazoline, loracarbef
, and cefloxitin may indicate the presence of
TABLE 4 Compliance-Enhancing Ranking of Antibiotic Suspensions STRONGLY COMPLIANCE-ENHANCING * Amoxicillin * Cefdinir (Omnicef) * Loracarbef
(Lorabid) * Cefaclor (Ceclor) * Cefixime (Suprax) MODERATELY COMPLIANCE-ENHANCING * Cefprozil (Cefzil) * Ceftibuten (Cedax) EQUIVOCAL COMPLIANCE-ENHANCING * Azithromycin (Zithromax) NOT COMPLIANCE-ENHANCING * Amoxicillin-clavulanate (Augmentin) * Erythromycin-sulfasoxazole (Pediazole) * TMP-SMX (Bactrim or Septra) DISCOURAGES COMPLIANCE * Cefpodoxime (Vantin) * Cefuroxime (Ceftin) * Clarithromycin (Biaxin) TMP-SMX, trimethoprim sulfamethoxazole Sources: Adapted from Steele RW, et al.
A total of 4,782 children were randomized to treatment with 10 days of penicillin, or 5 days of amoxicillin and potassium clavulanate (Augmentin), ceftibuten (Cedax), cefuroxime axetil (Ceftin), loracarbef
(Lorabid), clarithromycin (Biaxin), or erythromycin.