loop diuretics


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Related to loop diuretics: potassium sparing diuretics

loop diuretics

Drugs that lead to a large output of water in the urine by interfering with the reabsorption of sodium and chloride in the loop of Henle tubules in the kidneys. They include FRUSEMIDE (furosemide) (Fru-Co, Frumil, Frusene, Frusol, Lasikal, Lasilactone, Lasix); BUMETANIDE (Burinex, Burinex A, Burinex K); and torasemide (Torem). Frusemide is commonly formulated in combination with the thiazide diuretic AMILORIDE.

diuretics

powerful drugs, often termed 'water tablets', that control hypertension and peripheral oedema; action of some local anaesthetics is antagonized by concomitant use of some diuretics (see Table 1), e.g. aldosterone antagonists (e.g. spironolactone); carbonic anhydrase inhibitors, e.g. acetazolamide; loop diuretics, e.g. furosemide; osmotic diuretics, e.g. mannitol; potassium-sparing diuretics, e.g. amiloride, or in combination with other diuretics; thiazide diuretics, e.g. bendroflumethiazide
Table 1: Principal drug interactions of local anaesthetic agents and other medications
Local anaesthetic agent Proprietary name Principal drug interactionsEffect of interaction
Lidocaine
Xylocaine
Antiarrhythmic agents
Antibacterial agents
Antipsychotics
Antivirals
Beta-blockers
Diuretics
Dolasetron
Ulcer-healing drugs
Increased myocardial depression
Increased risk of ventricular arrhythmias if lidocaine is given with quinpristin/dalfopristin
Increased risk of ventricular arrhythmias if lidocaine is given with any drug that prolongs the QT interval of the cardiac cycle
Plasma concentration of lidocaine increased by amprenavir, atazanavir and lopinavir
Increased myocardial depression
Increased risk of lidocaine toxicity when given with propranolol
The action of lidocaine is antagonized by the hypokalaemia caused by acetazolamide, loop diuretics or thiazide and related diuretics (i.e. a greater dose of lidocaine would be required to achieve anaesthesia)
Increased risk of ventricular arrhythmia if lidocaine is given with dolasetron
Plasma concentration of lidocaine increased when given with cimetidine; risk of lidocaine toxicity increased with cimetidine
Bupivacaine
Marcain
Levo-bupivacaine
Chirocaine
Beta-blockersIncreased risk of bupivacaine toxicity when given with propranolol
Increased risk of myocardial depression if given with other antiarrhythmic agents
Prilocaine
Citanest
Antiarrhythmic agents
Antibacterial agents
Increased risk of myocardial depression if given with antiarrhythmic agents
Increased risk of methaemoglobinaemia if given with sulphonamide antibacterial agents
Ropivacaine
Naropin
AntidepressantsMetabolism of ropivacaine is inhibited by fluvoxamine, thereby enhancing the risk of ropivacaine toxicity
Mepivacaine
Scandonest
Drug not listed in the British National Formulary
References in periodicals archive ?
Loop diuretics have been shown to accelerate NOF in hypertensive patients who use them continuously for more than three years.
Beyond aggressive treatment with loop diuretics, what else is useful in achieving the goal of hospital discharge with normalized filling pressures?
The key to next differentiate these 2 possibilities is measuring urine calcium excretion, which is high in BS (owing to a mutation in 1 of 5 different genes in the TAL, the region of the kidney impacted by loop diuretics and important for calcium reabsorption), but low in GS (owing to a mutation in NCCT).
Thiazide and loop diuretic are no doubt very effective anti-hypertensive drugs and they are also economically priced but they are not for every patient suffering from high blood pressure.
Once the diagnosis made immediate treatment by loop diuretics, sodium replacement.
Furosemide from Lasix, Sanofi-Aventis Farmaceutica, a highceiling loop diuretic, was used as reference drug (positive control).
angiotensin-converting enzyme inhibitors, cyclosporine, diuretics: loop diuretics and thiazides; non-steroidal anti-inflammatory drugs, tetracycline), overdose, renal insufficiency, schizophrenia, surgery and volume depletion are among the factors that increase the risk for toxicity in previously stable patients (4).
MEDICATIONS THAT MAY AFFECT CALCIUM ABSORPTION Loop diuretics Furosemide (Lasix), bumetanide (Bumex), torsemide (Demadex) Cortico steroids Cortisone, prednisone, prednisolone (Prelone), methylprednisolone (Medrol) Heartburn medications Esomeprazole magnesium (Nexium), omeprazole (Prilosec), lansoprazole (Prevacid), cimetidine (Tagamet), ranitidine hydrochloride (Zantac) Laxatives Ex-Lax, Correctol
The presently available diuretics such as thiazides and loop diuretics exhibit various adverse effects, such as electrolyte imbalance and metabolic alterations.
It is well accepted that the therapeutic approach of decompensated CHF includes the use of intravenous loop diuretics to decrease sodium and water retention.
In the study, RLX030 was given on admission to the hospital in the form of an intravenous infusion for up to 48 hours in addition to loop diuretics and other medicines and was compared to placebo on top of standard of care treatment for AHF.