locally advanced

locally advanced

Large or bulky; said of a malignant tumor that has grown substantially at its site of origin.
References in periodicals archive ?
While the median time to response was less than 2 months, about one-fifth of patients with locally advanced disease had "unconventional" late responses, occurring up to 10 months after starting treatment, Dr.
Keytruda is approved for patients with recurrent locally advanced or metastatic ESCC whose tumors express PD-L1 as determined by an FDA-approved test, with disease progression on or after one prior line of systemic therapy.
Food and Drug Administration for the investigational agent enfortumab vedotin for the treatment of patients with locally advanced or metastatic urothelial cancer who have received a PD-1/L1 inhibitor and who have received a platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced or metastatic setting.
M2 PHARMA-July 17, 2019-Seattle Genetics and Astellas Submit Biologics License Application to FDA for Enfortumab Vedotin for Patients with Locally Advanced or Metastatic Urothelial Cancer
The European Commission (EC) has approved US-based Pfizer's Talzenna intended to treat patients with inherited (germline) BRCA-mutated locally advanced or metastatic breast cancer, it was reported on Monday.
Except for very early cases, radiation therapy is the major curative treatment option [5] and brachytherapy plays an anchor role in management of locally advanced disease.
Combined modality approaches have been developed in an effort to enhance locoregional disease control, reduce distant metastatic spread and improve survival in patients with locally advanced inoperable head and neck cancer2,4.
Healthcare company Janssen Pharmaceutical Companies of Johnson & Johnson reported on Friday the receipt of the US Food and Drug Administration (FDA) accelerated approval for BALVERSA (erdafitinib) for treating adults with locally advanced or metastatic urothelial carcinoma (mUC), a form of bladder cancer.
FOOD and Drug Administration has approved cemiplimab-rwlc (Libtayo) for the treatment of metastatic or locally advanced cutaneous squamous cell carcinoma, the agency announced in a press release.
WEDNESDAY, May 2, 2018 (HealthDay News) -- For patients with locally advanced esophageal cancer, the status of lymph nodes following preoperative neoadjuvant chemotherapy or chemoradiation therapy determines survival, according to a study presented at the annual meeting of the American Association for Thoracic Surgery, held from April 28 to May 1 in San Diego.
In locally advanced tumors, it is hard to differentiate neoplastic invasion from inflammatory adhesions intraoperatively.
Merck and Pfizer have initiated a Phase III study, JAVELIN Ovarian 100, to evaluate the efficacy and safety of avelumab in combination with, and/or as follow-on (maintenance) treatment to, platinum-based chemotherapy in patients with locally advanced or metastatic disease (Stage III or Stage IV) with previously untreated epithelial ovarian cancer.

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