insertional, site-specific, conditional knockout vectors or systems); 2) development and/or use of techniques supporting more efficient targeting of induced local lesions
in genomes (TILLING); 3) development and/or use of technologies for gene inactivation and for gene expression manipulation including, but not limited to, morpholino oligonucleotides, new types of antisense technology, techniques for homologous recombination, techniques for gene trapping, and strategies for directing gene misexpression, or other transgenic methodologies; 4) development of high throughput small molecule screens; 5) development of new genetic or genomic resources that are of high priority for the Xenopus community; 6) development and/or application of novel screens for mutants.
Samuel (1931) first reported that at the high temperature of 35[degrees]C Tobacco mosaic virus (TMV) produced chlorotic lesions and a systemic mottle in Nicotiana glutinosa instead of the necrotic local lesions
produced at lower temperatures.
Although generally not useful for the detection of noncontiguous spread, CT is ideally suited to define the extent of local lesions
, especially in anatomic sites where there are abundant fatty planes between muscle bundles.
CXR--WNL, ECG--WNL, USG A/P--Liver appears normal in size shows surface nodularities with altered parenchymal echotexture (cirrhotic changes), no local lesions
, IHBR not dilated, few periportal collaterals noted.