lobeline


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to lobeline: hydrastine

lo·be·line

, lobelin (lō'bĕ-lēn, lob'ĕ-lēn, -lin),
A piperidylacetophenone; an alkaloid of lobelia with the same actions as nicotine, but with less potency.

lobeline

An alkaloid found in Indian tobacco (Lobelia inflata) and other Lobelia species which has been used to manage tobacco and drug addictions, in part by acting as a vesicular monoamine transporter 2 (VAMT2) ligand, increasing or decreasing dopamine release (depending on the receptor to which it binds). Lobeline usually evokes emesis and, if absorbed in excess, may have toxic effects.

lobeline

A mixture of alkaloids with action similar to nicotine. Lobeline is derived from plants of the Lobelia genus and has been used as a respiratory stimulant, but is of little medical importance.

lobeline

a poisonous alkaloid found in plants of lobelia spp.
References in periodicals archive ?
Respiratory responses of mature horses to intravenous lobeline bolus.
In addition to Clearazide and Lobeline, the company is developing Nornicotine as a once a day oral drug for smoking cessation.
We could show for the first time in our studies that lobeline can moderately inhibit P-gp mediated efflux and reverse P-gp dependent resistance at non-toxic concentrations.
Lobeline, verapamil, doxorubicin, MTT, rhodamine 123, G418, mitoxantrone, and other chemicals were from Sigma Aldrich.
Yaupon's progress in advancing lobeline into human studies was supported by an investment earlier this year from BioAdvance, the Biotechnology Greenhouse of Southeastern Pennsylvania.
NASDAQ:DYGN; BSE:DYG) today announced that the United States Patent and Trademark Office has issued a notice of allowance for the company's application for its proprietary transdermal delivery system for the administration of lobeline as an aid to smoking cessation.
mp3 ) and to all the media, nationwide, and to Westwood One and MJI /Clear Channel and to Lobeline Communications for all their help in getting this to all of you.
While we are disappointed with the overall results of this trial, the Company has to-date shown that lobeline is a safe and potentially effective non-nicotine alternative smoking cessation therapy for some smokers wanting to quit," said Dr.
Nasdaq: DYGN;BSE: DYG) today announced that it has licensed worldwide, exclusive rights to develop a lobeline sulfate nasal delivery formulation, NicErase(R)-NS, to Nastech Pharmaceutical Company Inc.
Several manufacturers of the non-prescription products have discussed with FDA the possibility of conducting clinical trials on lobeline sulfate and silver acetate -- two ingredients in products now on the market.