loading dose


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Related to loading dose: maintenance dose

dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

load·ing dose

a comparatively large dose given at the beginning of treatment to start getting the effect of a drug, especially one with slow clearance, thus requiring a long period to achieve stable blood levels without a high initial dose.
Synonym(s): initial dose

loading dose

Initial dose Pharmacology A first dose of a drug administered in excess of the maintenance dose, administered to rapidly achieve therapeutic drug levels. Cf Maintenance dose.

load·ing dose

(lōd'ing dōs)
The first dose of a medicine, which is much larger than the following doses, to reach a therapeutic level more rapidly.

load·ing dose

(lōd-ing' dōs)
Comparatively large dose given at beginning of treatment to start getting the effect of a drug.
Synonym(s): initial dose.
References in periodicals archive ?
Fewer patients received ticlopidine than clopidogrel and there were only three patients who received a high loading dose of ticlopidine.
Vomiting was the most common side effect reported in children after loading doses of fosphenytoin.
The ED50 and ED95 of the loading dexmedetomidine to achieve RSS [greater than or equal to] 3 at 5 min after the loading dose were estimated to be 0.82 [micro]g [kg.sup.-1] (95% confidence interval [CI] 0.73-0.89 [micro]g [kg.sup.-1]) and 0.96 [micro]g [kg.sup.-1] (95% CI 0.90-1.39 [micro]g [kg.sup.-1]).
before induction of anaesthesia had significant decrease in MAP and HR after administration of loading dose. This dexmedetomidine induced haemodynamic profile can be attributed to the known sympatholytic effect of [alpha]2 agonists.
infusion over two and half hours as loading dose was administered and then 30 mg colistin sulfate/kg body weight I/M for next six days.
All patients received the same drug delivery mode, with which their respective drug was infused at a loading dose of 0.125 ml/kg over 10 min followed by a continuous infusion of 0.0625 ml*kg [sup]−1*h [sup]−1 via a pressure-driven syringe pump.
(5) Similarly, another advocate found that of 4065 patients tested, less than 1% excreted more than 90% of the 50 mg iodine/iodide loading dose. (6) Both studies indicate an extremely high rate of iodine insufficiency in tested subjects.
Patients assigned to ticagrelor received a loading dose as soon as possible after randomisation.
Singla, M.D., from Lotus Clinical Research in Pasadena, California, and colleagues randomly assigned 401 patients with moderate-to-severe acute postoperative pain following abdominoplasty to a loading dose of placebo, oliceridine (1.5 mg), or morphine (4 mg), followed by demand doses administered through patient-controlled analgesia (0.1, 0.35, or 0.5 mg oliceridine; 1 mg morphine; or placebo) with a six-minute lockout interval.
Subjects are dosed for 5 days and receive a once-daily 600 mg dose, a single 500 mg loading dose followed by 300 mg twice daily, or placebo.