liver metastasis


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liver metastasis

Oncology Cancer that has spread from the original–1º–tumor to the liver Primary cancer Colorectal CA, neuroblastoma, pancreatic CA, Hodgkin's lymphoma. See Metastasis.
References in periodicals archive ?
OBJECTIVE: To observe the expression of galectin-3 in the liver metastasis of colon cancer in mice and the inhibitory effect of modified citrus pectin (MCP) on galectin-3 expression.
The remaining patient (patient 5), who had presented with a liver metastasis, received chemotherapy and palliative local radiotherapy.
The aim of this study was to clarify the association between the mRNA levels of cyclooxygenase-2 (COX-2) and angiogenic factors vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) in primary CRC and those in corresponding liver metastasis.
Treatment of liver metastasis varies depending on the site of the original cancer, the extent of cancer spread to the liver and many other factors.
Staging examinations with CT scan after the first cycle of treatment showed a partial remission with reduction of the liver metastasis down to 51 x 33 mm, and with decreased obstruction of the intrahepatic biliary tract.
One of the four complete responses occurred in a patient with a single liver lesion and three were observed in patients with multiple sites of liver metastasis.
An eighth with pancreas cancer had a substantial decrease of a liver metastasis.
In a liver metastatic mouse model, sapacitabine was shown to be superior to gemcitabine (Gemzar(R); Lilly) or 5-FU, two widely used nucleoside analogues, in delaying the onset and growth of liver metastasis.
A sixth with pancreas cancer had a mixed response with a substantial decrease of a liver metastasis.
The Company is completing a Phase 3 clinical trial for advanced malignant melanoma with liver metastasis that will be used for regulatory filing in the US and is pending regulatory approval in Europe.
Additional studies using this delivery nanotechnology are planned for treatment of liver metastasis and refractory solid tumors by the IV route;
Although 25-40 percent of patients with isolated liver metastasis can be cured with surgery, a significant number of patients will not benefit from such aggressive intervention.