Large foci of cellular alteration (LFCA) were lesions larger than a liver lobule
that did not compress the adjacent liver but had alterations in architecture and staining or cellular characteristics.
The increased demand for oxygen, in turn, can lead to oxygen deficits at least in certain regions of the liver lobules
(i.e., the perivenous region).
Sinusoids: Channels in a liver lobule
that conduct blood and nutrients to the hepatocytes, similar to capillaries in other organs.
These liver sections provided well-marked liver lobules for the analysis--vide supra.
Next, we examined the anatomical sites of FVIIIRAg immunoreaction within the liver lobules. FVIIIRAg stained sinusoidal endothelial cells were commonly observed in the periportal parenchyma nearby enlarged fibrotic portal tracts (Figure 6(a)).
While these findings principally corroborate the studies of others reporting transformation of liver sinusoidal endothelium to FVIIIRAg-positive cells in advanced hepatic fibrotic disease of various causes [9, 10, 15-17], our study of aged cadavers with progressive stages of fibrosis also provides important data on the anatomical sites of FVIIIRAg expression as well as the histopathology of sinusoidal transformation to vascular endothelium within the liver lobules that have not previously been described.
It is known that the pathogenesis of vascular endothelium in the liver lobules is accompanied by the formation of a basement membrane beneath the endothelium in the space of Disse.
The findings suggest that, at these early stages of liver fibrosis, vessels within the liver lobules remain largely sinusoidal and, thus, may have little impact on the exchange of materials between the sinusoidal blood and liver parenchyma.
Further study has revealed differences in the extent of lesions among the liver lobules
. The Tox/Path team has designed studies to evaluate the distribution of lesions throughout the liver.
Acetaldehyde adducts are found predominantly in a certain region of the liver lobules (2) (i.e., the perivenous region, which is located around the small vein through which the blood exits the lobule).
(2) Liver lobules are the functional units of the liver, a human liver consists of approximately 50,000 to 100,000 lobules.