hepatic diverticulum

(redirected from liver bud)

hepatic diverticulum

the primordial cellular diverticulum of the embryonic foregut endoderm that gives rise to the parenchyma of the liver.
Synonym(s): liver bud

he·pat·ic di·ver·tic·u·lum

(he-pat'ik dī'vĕr-tik'yū-lŭm)
An outgrowth of endodermal epithelium from the caudal part of the embryonic foregut (future site of duodenum); it gives rise to the liver, gallbladder, cystic duct, and bile ducts.
Synonym(s): liver bud.


emanating from or pertaining to liver.

hepatic abscess
common in cattle as a sequel to rumenitis; characterized by fever, leukocytosis and pain on percussion over the liver.
hepatic acinus
see liver acinus.
hepatic angle
the angle made by the caudolateral border of the caudate liver lobe on abdominal radiography.
hepatic arterioportal fistula
shunt between the hepatic artery and the portal vein.
hepatic atrophy and nodular regeneration
a disease of dogs, due to unknown cause but possibly a toxin, characterized by nodular regenerative hyperplasia and atrophy of severely fatty hepatocellular parenchyma and gradually developing, always fatal, liver insufficiency.
hepatic cell
hepatic cirrhosis
diffuse hepatic fibrosis associated with the formation of structurally abnormal, regenerative, parenchymal nodules. Initiated by hepatocyte necrosis.
hepatic coccidiosis
spoken of but recorded only once in a calf.
hepatic congestion
a common feature of congestive heart failure and other circulatory embarrassments of venous drainage of the liver; occurs also in anaphylaxis.
diffuse hepatic fibrosis
results from continued, chronic hepatic injury or the summation of repeated bouts of zonal necrosis; the resulting fibrosis links portal areas and hepatic venules and bisects liver lobules.
hepatic distomatosis
infection of the liver with flukes, e.g. Fasciola hepatica, Fascioloides magna, Metorchus conjunctus. See also fascioliasis.
hepatic diverticulum
an outgrowth of the embryonic duodenum; it divides into a pars hepatica and a pars cystica, forerunners of the liver and the gallbladder respectively.
hepatic duct
see hepatic duct.
hepatic fibrosis
a reaction to chronic injury to the liver; includes biliary fibrosis, postnecrotic scarring, diffuse hepatic fibrosis and periacinar fibrosis.
Enlarge picture
Hepatic fibrosis with nodular hyperplasia. By permission from Nelson RW, Couto CG, Small Animal Internal Medicine, Mosby, 2003
hepatic injury
hepatic jaundice
jaundice caused by disease of hepatic parenchyma in contrast to hemolytic and obstructive jaundice.
hepatic lipidosis
see fatty liver.
hepatic microsomal enzymes
see microsomal enzymes.
hepatic necrosis
death of hepatic parenchyma which may be single cell (necrobiosis), or multicell in piecemeal, focal, periacinar, midzonal, periportal or paracentral locations. Massive necrosis refers to events in individual acini in which all hepatocytes are dead.
omphalogenic hepatic abscess
abscess resulting from infection of the umbilicus and direct vascular extension to the liver.
hepatic periacinar fibrosis
fibrosis limited to the zones around hepatic venules; a response to congestive heart failure or to intoxication.
hepatic photosensitization
see secondary photosensitization.
hepatic sinusoids
the intralobular vascular supply system; lined by endothelial cells and stellate macrophages.
References in periodicals archive ?
The new cellular and molecular data uncovered in the current study will be "exploited in the future to further improve liver bud organoids" and "precisely recapitulate differentiation of all cell types" in fetal human development, the authors write.
The septum transversum mesoderm is known to support the growth of the liver bud (11-14).
Abnormal migration of some portion of hepatic diverticulum or the liver bud to other tissues is believed to be the cause of ectopic liver.
During embryonic development, BMP4 plays an important role in liver bud formation (Duncan and Watt 2001).
The cells self-assembled and organized into a liver bud," says Ken Zaret, a developmental biologist at the University of Pennsylvania in Philadelphia.
We just simply mixed three cell types, including the human iPS-derived hepatic progenitors, and found that they unexpectedly self-organise to form a three dimensional liver bud," said Prof Takebe.
However, to their surprise the cells started to organise themselves and started curling to form a liver bud.
When they grafted the liver bud into a mouse, the team said the tiny organ's blood vessels worked correctly and it successfully metabolised some drugs that human livers metabolise but which mouse livers normally cannot.
The subsequent midgut extends from the bottom of the liver bud to the end point of the two-thirds of proximal part of the transverse colon.
Several theories have been proposed to explain the development of ectopic liver at different sites: development of an accessory lobe of the liver with atrophy or regression of the original connection to the main liver, (4) migration or displacement of a portion of the cranial part (Pars hepatica) of the liver bud to other sites, (6) dorsal budding of hepatic tissue before the closing of the pleuroperitoneal canal (may explain how EL develops in the thoracic cavity such as esophagus, pericardium, intra pleural or extra pleural), (7) trapping of hepatocyte-destined mesenchyma in different areas (8) and entrapment of nests of cells in the region of the foregut following closure of the diaphragm or umbilical ring.
Because we can now overcome these obstacles to generate highly functional, three-dimensional liver buds, our production process comes very close to complying with clinical-grade standards," lead researcher Takanori Takebe said.
Now, if the tissue colon is weak where the liver buds, you probably have a bad liver and the iris will show some specific signs.