We report the use of dermoscopy to further characterize such lesions in patients with early, non-ulcerated livedoid vasculopathy without clotting disorders.
Five consecutive patients (four females and one male between 43 and 50 years old) with painful livedoid vasculopathy of the ankles without ulcerations and without venous insufficiency were evaluated.
Glomerular vessels are not specific to livedoid vasculopathy. They have been described in chronic sun-damaged skin with precancerous lesions (5-7), in the periphery of hyperkeratotic Bowen's disease (8) and basal cell carcinoma (9), in poromas (10), in psoriasis (11), and in cutaneous leishmaniasis (12, 13).
Livedoid vasculopathy is an uncommon disease and is a purely cutaneous form of ischemia.
. The role of hyperhomo-cysteinemia and its simple therapeutic consequences.
Livedoid vasculopathy, also known as atrophie blanche and PURPLE (painful purpuric ulcers with reticular pattern of the lower extremities) is a rare, chronic vascular condition.
Livedoid vasculopathy may have periods of activity and remission.
We observed markedly enhanced functional stability of PAI-1 in patients with a rare thrombotic skin condition: livedoid vasculopathy .
observed that the functional stability of PAI-1 was markedly increased (nearly 43-fold) in plasma from the patients with thrombotic skin disorder such as livedoid vasculopathy. The mechanism of enhancing functional stability of PAI-1 activity is unknown.
Eren et al., "Enhanced functional stability of plasminogen activator inhibitor-1 in patients with livedoid vasculopathy," Journal of Thrombosis and Thrombolysis, vol.
Of the 78 patients in the cohort who had autoimmune disease, most had rheumatoid arthritis, lupus or livedoid vasculopathy
, a type of vascular disease.
In all of the cases analyzed, a differential diagnosis was performed between EG and Warfarin-induced skin necrosis, cocaine-induced skin necrosis, calciphylaxis, septic emboli, loxoscelism, diabetic microangiopathy, disseminated intravascular coagulation, necrotizing vasculitis, paraneoplastic extensive necrotizing vasculitis, pyoderma gangrenosum, livedoid vasculopathy
, necrotizing fasciitis, and necrosis secondary to the use of vasoactive drugs.