livedoid vasculopathy

livedoid vasculopathy

A thrombogenic vasculopathy caused by fibrin thrombi in the small dermal vessels of the lower legs, especially in older women, which are attributed to decreased fibrinolytic activity in the blood coupled with defective release of intrinsic tissue plasminogen activator from vessel walls. The typical lesions are telangiectatic purpuric papules and plaques which evolve into crusted ulcers that heal into atrophic stellate scars.

Associations
Patients may also have livedo reticularis, scleroderma, systemic lupus erythematosus and cryoglobulinaemia.
References in periodicals archive ?
In all of the cases analyzed, a differential diagnosis was performed between EG and Warfarin-induced skin necrosis, cocaine-induced skin necrosis, calciphylaxis, septic emboli, loxoscelism, diabetic microangiopathy, disseminated intravascular coagulation, necrotizing vasculitis, paraneoplastic extensive necrotizing vasculitis, pyoderma gangrenosum, livedoid vasculopathy, necrotizing fasciitis, and necrosis secondary to the use of vasoactive drugs.
Of the 78 patients in the cohort who had autoimmune disease, most had rheumatoid arthritis, lupus or livedoid vasculopathy, a type of vascular disease.