Those bile acids go to the small intestine and are broken down into secondary bile acids, one of which is lithocholic acid.
While the research identifies a possible target for helping the body eliminate excess lithocholic acid, exploiting the research might not be as simple.
Lithocholic acid can break apart DNA strands, form bonds with DNA that disrupt genes, and inhibit DNA repair.
One bound to a broad range of bile acids, including lithocholic acid. The other bound just to lithocholie acid, but only weakly.
They found that it "only interacts with lithocholic acid and some of its close metabolites.
Abbreviations BA: Bile acid BO: Biliary obstruction CA: Cholic acid CDCA: Chenodeoxycholic acid DCA: Deoxycholic acid FXR: Farnesoid X receptor G: Glucuronide HDCA: Hyodeoxycholic acid HCA: Hyocholic acid LCA: Lithocholic acid LC-MS/MS: Liquid chromatography-tandem mass spectrometry UDPGA: UDP-glucuronic acid UGT: UDP-glucuronosyltransferase MRPs: Multidrug resistance related proteins.
Hofmann, "Detoxification of lithocholic acid, a toxic bile-acid: relevance to drug hepatotoxicity," Drug Metabolism Reviews, vol.
Human liver (black squares, pool of 50 donors) and kidney (white diamonds; pool of 8 donors) microsomes (10 [micro]g) were incubated in the presence of increasing concentrations (1 to 350 [micro]M) of lithocholic acid (LCA, (a) and (b)) or deoxycholic acid (DCA, (c) and (d)) for 2 hours at 37[degrees]C.
Abbreviations: CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; G, glycine-conjugated; LCA, lithocholic acid
; MCA, muricholic acid; NS, not significant; T, taurine-conjugated species; UDCA, ursodeoxycholic acid.
The minimum 15-mL dose of sheep bile contains an estimated average 271 mg of bile acids (including 47% deoxycholic, 25% chenodeoxycholic, 23% cholic, and 5% lithocholic acids
) - the equivalent of 36% of the maximum daily dose of bile acids used for treating cholelithiasis and 9% of the total bile acid pool (3.0 g) in adults (4,7).