lithium carbonate


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

lithium

 (Li) [lith´e-um]
a chemical element, atomic number 3, atomic weight 6.939. (See Appendix 6.)
lithium carbonate a psychotropic drug used to treat acute manic attacks in bipolar disorder and, when given on a maintenance basis, to prevent the recurrence of manic-depressive episodes. The desired serum levels are in the range 0.5–1.5 mEq/L. Life-threatening central nervous system effects and kidney damage occur at levels above 3.0 mEq/L. It is very important that the levels be carefully controlled. Lithium should not be given to patients with severe renal or cardiovascular disease or taken with diuretics because the potential for toxicity is very high. It is suspected of causing birth defects and should not be used during pregnancy.
lithium citrate the citrate salt of lithium, having the same actions and uses as the carbonate salt.

lith·i·um car·bon·ate

an agent used in the treatment and prophylaxis of depressive, hypomanic, and manic phases of bipolar affective disorders.

lithium carbonate

n.
A white granular powder, Li2CO3, used as a drug primarily to treat bipolar disorder and in the manufacture of glass and ceramics.

lithium carbonate

an antimanic agent.
indication It is prescribed in the treatment of manic episodes of manic-depressive disorder.
contraindications It is used with caution in the presence of renal or cardiovascular disease and is not recommended for children under 12 years of age. Known hypersensitivity to this drug and pregnancy prohibit its use.
adverse effects Among the most serious adverse effects are renal damage, polydipsia and polyuria, and impairment of mental and physical abilities. Retention of sodium and fluid may occur.

lithium carbonate

LiCO3 Pharmacology An alkali used to treat bipolar I disorder, which blocks neurotransmission at the 'second messenger' phosphoinositide-mediated cholinergic neurons in the hippocampus , inhibiting release and uptake of norepinephrine at nerve endings by inhibiting receptor-mediated synthesis of cAMP Neuropharmacologic effects-antimanic Blocks development of dopamine receptor supersensitivity, ↑ GABA function, ↑ acetylcholine function Antidepressant ↑ 5-HT function, ↓ β-adrenoceptor stimulation of adenylate cyclase, ↓ α2-adrenoceptor function Thymoleptic ↓ Neurotransmitter-coupled adenylate cyclase activity and cAMP formation, ↓ receptor-G protein coupling, ↓ phosphoinositide metabolism, alters kinetics of alkali cations–Na+, K+, Ca2+, Mg2+  Side effects Hyperirritability, hyperpyrexia, stupor, coma, gastroenteritis, cardiovascular disease–eg, arrhythmia, hypotension, ↓ ST wave, T inversion, osteoporosis Teratogenesis Cardiac malformations in 10% of infants born to lithium-treated ♀ Toxicity Overdose causes death in14 of Pts Treatment K+-sparing drugs
Lithium toxicity
< 1.5 mmol/L Nausea, tremor, mild polyuria
1.5–2.5 mmol/L Diarrhea, vomiting, polyuria, coarse tremor, muscle fasciculation, ataxia, weakness, sedation
2.5–4.0 mmol/L Muscle hypertonia, choreiform movement, ↑ deep muscle reflexes, seizures, focal neurologic signs, impaired consciousness, confusion, stupor
> 4.0 mmol/L Coma, death

lith·i·um car·bon·ate

(lith'ē-ŭm kahr'bŏ-nāt)
Agent used to treat depressive, hypomanic, and manic phases of bipolar affective disorders.

lithium carbonate

agent used in the prophylaxis and treatment of bipolar disorder and recurrent depression; side-effects include renal impairment, polydipsia and polyuria, weight gain and oedema, drowsiness, ataxia, coarse tremor and reduced coordination; may increase rate of plantar callous formation

lith·i·um car·bon·ate

(lithē-ŭm kahrbŏ-nāt)
Agent used to treat depressive, hypomanic, and manic phases of bipolar affective disorders.

lithium

a chemical element, atomic number 3, atomic weight 6.939, symbol Li. See Table 6.

lithium carbonate
used in the treatment of canine cyclic hematopoiesis to stabilize numbers of neutrophils.
References in periodicals archive ?
China's lithium carbonate import growth has slowed down since 2005, and its import quantity's absolute value has declined year by year.
From Sal de Vida, Galaxy plans to produce 25,000 tpa of lithium carbonate and 100,000 tpa of saleable potash-by product.
By the end of 2008, the global lithium carbonate demand was 95,400 tons, up 2.
According to IMS Health, the Lithium Carbonate Extended-release Tablets USP, 300 mg, had US sales of approximately USD21m for the 12 months ending 31 March 2012.
The study is for a Stage I development plan with proposed production of 25,000 tonnes per year of high-quality, low-impurity lithium carbonate beginning in 2013.
Concurrently with a USD75m expansion of its lithium production in the United States, which includes expansion of its brine pond system at Silver Peak, NV and construction of a battery grade lithium hydroxide plant and a global technical centre at Kings Mountain, NC the investment will increase total annual production capacity to 50,000 metric tons of lithium carbonate equivalent by end of 2013, the company added the US sites are expected to be on stream by spring 2012.
Upcoming milestones for the project include submission of the Plan of Operations to the Bureau of Land Management during the first quarter of 2012, which will initiate the formal permitting process; starting construction of a lithium carbonate demonstration plant; and starting work on a definitive feasibility study.
By 2011, Galaxy's Mt Cattlin mine will be the world's second largest producer of lithium mineral concentrate globally, and through the development of its 17,000 tpa lithium carbonate plant in Jiangsu province, the Company expects to be one of the largest and lowest cost lithium compound producersin China.
Because of its high value application, battery grade lithium carbonate receives a significant price premium to more common technical grades.
Depending on the product grade, the company stated it will increase its lithium carbonate prices by 20% and between 15% and 25% for its range of lithium products, including lithium hydroxide, lithium chloride, specialty lithium salts and lithium battery metal, respectively.
com/research/e89a13/global_china_lit) has announced the addition of the "Global & China Lithium Carbonate Industry Report, 2008-2010 (Updated Version)" report to their offering.