lissencephaly


Also found in: Dictionary, Acronyms, Wikipedia.

lissencephaly

 [lis″en-sef´ah-le]
agyria. adj., adj lissencephal´ic.

a·gy·ri·a

(ā-jī'rē-ă),
Congenital lack or underdevelopment of the convolutional pattern of the cerebral cortex.
[G. a- priv. + gyros, circle]

lissencephaly

/lis·sen·ceph·a·ly/ (lis″en-sef´ah-le) agyria.lissencephal´ic

lissencephaly

See agyria.

lissencephaly

Neurology A brain malformation that is isolated or associated with other syndromes–eg, Miller-Dieker syndrome, Norman-Roberts syndrome, characterized by absence–agyria or incomplete development–pachygyria of cerebral gyri Clinical Microcephaly, seizures, profound mental retardation, feeding difficulties, growth retardation, impaired motor activity

Miller,

James Q., U.S. physician.
Miller-Dieker syndrome - arrested brain development. Synonym(s): lissencephaly; Norman-Roberts syndrome

lissencephaly

a malformation in which the gyri of the cerebral cortex are not normally developed. In dogs it has been associated with behavioral abnormalities, visual deficits, ataxia and seizures. Called also agyria.
References in periodicals archive ?
Because there are no relevant animal models for lissencephaly, the reprogramming technique has been essential to the study of lissencephaly's underlying pathogenesis.
These clinical signs were similar to those reported in cases of lissencephaly and cerebellar hypoplasia in dogs, cats (MACKILLOP 2011), and humans (AYALAet al" 2007).
Dobyns: The clinical patterns and molecular genetics of lissencephaly and subcortical band heterotopia.
Classic lissencephaly, cobblestone lissencephalies, polymicrogyria, schizencephaly, and heterotopia have all been described previously in conjunction with anomalies of the corpus callosum [33-35].
She suffers from several health complications including rare brain formation known as lissencephaly which means she is neurologically impaired due to a lack of development of brain folds.
schizencephaly, histiogenesis lissencephaly, polymicrogyria); phacomatosis (e.
The Liam Lawson Foundation for Pediatric Palliative Care Liam Lawson was diagnosed at the age of 4 months with a condition known as Lissencephaly.
Lissencephaly is characterized by a smooth brain surface due to a lack of gyri and sulci.
Washington, Sep 7 (ANI): By using protease inhibitors, researchers at the University of California-San Francisco (UCSF) have restored to normal levels a key protein that is involved in early brain development, and causes the rare brain disorder lissencephaly.
A persistently and significantly small fetal head with normal-appearing sonographic anatomy may, for example, reveal a lissencephaly syndrome on MRI exam.
Grace Horton, from Tamworth, was born in April 2008 with a rare brain disorder called Lissencephaly.
Grace was born with an extremely rare brain disorder called Lissencephaly, or Smooth Brain Disorder, which means that although her body will develop, mentally she will never grow up.