(15) ALK and ROSI testing is usually performed on an FFPE or a cytology sample (cytology smear, cytospin, or liquid-based cytology
) taken from a patient who has advanced disease (only ALK FISH has been FDA approved in FFPE tissue but not in conventional cytology).
does have a number of other unquestionable advantages, however:
The National Institute for Clinical Excellence (Nice) recommended last year that liquid-based cytology
should be used for all smear tests performed in England and Wales in the future.
Utility of liquid-based cytology
for cervical carcinoma screening: results of a population-based study conducted in a region of Costa Rica with a high incidence of cervical carcinoma.
The diagnostic and prognostic role of liquid-based cytology
: are we ready to monitor therapy and resistance?
For labs, there could be potential impact on testing mix and volume--with HPV DNA testing increasing and liquid-based cytology
* RESULTS The authors show that maximal saving in life years is achieved through screening every 2 years for life with combined HPV and Pap testing (using liquid-based cytology
media) at a cost of $76,183 per life-year saved.
Molecular diagnosis using residual liquid-based cytology
materials for patients with nondiagnostic or indeterminate thyroid nodules.
Combining HPV testing with liquid-based cytology
held little advantage over HPV testing alone, according to the results of the ATHENA trial published in the September issue of The Lancet Oncology.
"If you use a liquid-based cytology
specimen, a human papillomavirus (HPV) sample can be collected at the same time as the Pap smear, and you can instruct your lab to read it only if the Pap smear results are concerning," he commented at the Annual Southern Obstetric and Gynecologic Seminar.
ThinPrep, a liquid-based cytology
system, has garnered growing enthusiasm since its approval by the Food and Drug Administration in 1996.
The traditional cytology preparation consists of a smear, which is routinely used but often in combination with alternative and more newly introduced technique(s), including cell blocks (ie, cohesive cell pellets formed in a cytology laboratory and subsequently embedded in paraffin and processed like surgical specimens to generate hematoxylin-eosin [H&E] slides) and liquid-based cytology