liquid-based cytology


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Related to liquid-based cytology: smear test, Cervical cytology

liquid-based cytology

Abbreviation: LBC
A means of performing a Papanicolaou test (Pap test) in which the head of the plastic spatula used to obtain cells from the endocervix is inserted directly into a vial containing a fluid cellular preservative. The vial is spun in the laboratory, and a pellet of pure cells is obtained. This cellular layer is then deposited on a microscope slide and examined for evidence of cellular atypia or frank cancer. The liquid-based cytology differs from traditional cervical cytology in that the contents of the spatula are not smeared directly onto a microscope slide. This reduces the number of specimens received by the laboratory that are unable to be interpreted pathologically.
See also: cytology
References in periodicals archive ?
Human papillomavirus 16 load and E2/E6 ratio in HPV16-positive women: biomarkers for cervical intraepithelial neoplasia >2 in a liquid-based cytology setting.
The study findings suggest that that the use of HPV testing as the primary screening test to rule out cervical disease, along with a specific test such as liquid-based cytology to help determine which women should be sent for immediate colposcopy, is a rational approach.
This is called reflux testing and can be done from the same sample if liquid-based cytology is done.
Liquid-based cytology and conventional cervical smears: a comparison study in an Asian screening population.
The liquid-based cytology system will be available throughout Scotland by 2004.
A randomised comparison of SurePath liquid-based cytology and conventional smear cytology in a colposcopy clinic setting.
Liquid-based cytology test use by office based physicians: United States, 2006-2007.
Combining HPV testing with liquid-based cytology held little advantage over HPV testing alone, according to the results of the ATHENA trial published in the September issue of The Lancet Oncology.
The new test, known as liquid-based cytology screening, changes the way samples are handled and means the recall rate for inaccuracies is lower.
In liquid-based cytology the device used to collect the cell sample is rinsed off into a vial of preservative fluid and the slide prepared in the laboratory.
Health service watchdog the National Institute for Clinical Excellence (Nice) last night backed the use of liquid-based cytology (LBC) over the current Pap test for the diagnosis of cervical cancer.
The two sets of guidelines also differ regarding the use of liquid-based cytology for cervical screening.

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