1,11,12,13,14) Silver nitrate, phenol, and trichloracetic acid are used as chemical agents, while treatment options for immunocompromised patients with refractory lesions include topical cidofovir (5%), intralesional or systemic interferon, imiquimod cream (5%), salicylic acid, glycolic acid, tretinoin, tazarotene, 5% sodium nitrate, podophyllotoxin, liquefied phenol
, cantharidin, potassium hydroxide, 1% adenine cream, and oral cimetidine.
The phenol was applied with partially stripped cotton applicators, saturated with 88% liquefied phenol (distilled water was used as solvent), by vigorously massaging it into the matrix area.
Segmental matrix cauterization with liquefied phenol has been shown to be highly successfulin permanently destroying the lateral matrix.
7,10) Chemical agents such as silver nitrate, phenol and trichloroacetic acid, in resistant lesions in immunocompromised patients topical antiviral agent cidofovir (5%), intralesional or systemic interferon alpha, imiquimod (5%) cream, salicylic acid, glycolic acid, tretinoin, tazortene, 5% sodium nitrite co-applied daily with 5% salicylic acid topical preparations, podofilox, liquefied phenol
, tretinoin, cantharidin, potassium hydroxide, adapelene 1% cream have been reported.