lipoxin


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lipoxin

(li-pok'sin)
Any of a group of eicosanoids formed by the action of phospholipases on cell membrane phospholipids. Some lipoxins have anti-inflammatory effects, but some promote inflammation and hypersensitivity reactions. See: leukotriene; prostaglandin
References in classic literature ?
It was this, if I remember right: Jonah was swallowed by the whale in the Mediterranean Sea, and after three days he was vomited up somewhere within three days' journey of Nineveh, a city on the Tigris, very much more than three days' journey across from the nearest point of the Mediterranean coast.
These include Lipoxin A4, eosinophils and protectin D1.
Protective effect of lipoxin A4 against rhabdomyolysis-induced acute kidney injury in rats (in Chinese).
The NSAIDs exert therapeutic effects by inhibition of the cyclooxygenase (COX) enzymes, which block the conversion of arachidonic acid to proinflammatory prostaglandin mediators, and by blocking anti-inflammatory mediators such as lipoxin.
Moreover, it is important to remember that statins have pleotropic anti-inflammatory and antioxidant activities (Davignon and Ganz, 2004) and can also cause nitrosylation of COX-2, leading to an increase in the production of 15-epi-lipoxin A4, an anti-inflammatory eicosanoid lipoxin, which influences the biosynthesis of resolvins, which are important in the resolution of inflammation (Spite and Serhan, 2010).
Global Markets Direct's, 'N-Formyl Peptide Receptor 2 (FMLP-Related Receptor I or FMLP-R-I or Formyl Peptide Receptor-Like 1 or HM63 or Lipoxin A4 Receptor or RFP or FPR2) - Pipeline Review, H1 2016', provides in depth analysis on N-Formyl Peptide Receptor 2 (FMLP-Related Receptor I or FMLP-R-I or Formyl Peptide Receptor-Like 1 or HM63 or Lipoxin A4 Receptor or RFP or FPR2) targeted pipeline therapeutics.
Lipoxin A4 levels in asthma: relation with disease everity and aspirin sensitivity.
Lipoxins (such as lipoxin A4 and lipoxin B4) are unique structures derived from arachidonic acid that have potent actions in vivo and in vitro (Figure-1).
They found that macrophages contain the biochemical tools to not just initiate inflammation, a natural part of the immune response, but also to promote recovery from inflammation by releasing 15-HETE and converting it into lipoxin as the inflammation progresses.
Both mechanisms were controlled by a molecule called lipoxin A4, which is responsible for resolving inflammation.
Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation.