lipotoxicity

lipotoxicity

The pathologic changes in organs resultant from elevated fat levels in blood or tissues, as in the diabetic liver.

lipotoxicity

(lip″ŏ-tok-sis′ĭt-ē) [ lipo- + toxicity]
The adverse effects on glucose metabolism of excessive concentrations of free fatty acids in the blood. These effects include an increase in the resistance of the liver and muscle to the effects of insulin, an increase in glucose production, and reductions in insulin secretion by the pancreas.
References in periodicals archive ?
Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets.
T2DM is associated with insulin secretion disorder of [beta] cells and insulin resistance, which is defined as the deterioration of normal biological response to exogenous and endogenous insulin, and many resultants can be regarded, such as genetic factors, cellular receptor mechanism, low birth weight, obesity, lifestyle, glucotoxicity, lipotoxicity, islet amyloid, adiposyte products, and inflammation (6).
The critical role of Astragalus polysaccharides for the improvement of PPARa-mediated lipotoxicity in diabetic cardiomyopathy.
SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity.
The contributory mechanisms are mainly hyperglycaemia, lipotoxicity and insulin resistance in HFpEF and autoimmunity in HFrEF.
Instead, the interruption of triglyceride synthesis could be the initiating event for free fatty acid (FA)-mediated lipotoxicity that leads to NASH and fibrosis (Choi and Diehl 2008; Trauner et al.
Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis.
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway.
22] Other mechanisms such as lipotoxicity [23] and inflammation [24] resulting owing to high calorie intake are also likely causes of decline in p-cell functioning.
Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications.