Astragalus polysaccharides repress myocardial lipotoxicity
in a PPARalpha-dependent manner in vitro and in vivo in mice.
Endogenous GLP-1 as a key self-defense molecule against lipotoxicity
in pancreatic islets.
T2DM is associated with insulin secretion disorder of [beta] cells and insulin resistance, which is defined as the deterioration of normal biological response to exogenous and endogenous insulin, and many resultants can be regarded, such as genetic factors, cellular receptor mechanism, low birth weight, obesity, lifestyle, glucotoxicity, lipotoxicity
, islet amyloid, adiposyte products, and inflammation (6).
The critical role of Astragalus polysaccharides for the improvement of PPARa-mediated lipotoxicity
in diabetic cardiomyopathy.
SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity
The contributory mechanisms are mainly hyperglycaemia, lipotoxicity
and insulin resistance in HFpEF and autoimmunity in HFrEF.
Cannabinoid receptor 1 promotes hepatic lipid accumulation and lipotoxicity
through the induction of SREBP-1c expression in zebrafish.
Instead, the interruption of triglyceride synthesis could be the initiating event for free fatty acid (FA)-mediated lipotoxicity
that leads to NASH and fibrosis (Choi and Diehl 2008; Trauner et al.
Role of insulin resistance and lipotoxicity
in non-alcoholic steatohepatitis.
Free fatty acids promote hepatic lipotoxicity
by stimulating TNF-alpha expression via a lysosomal pathway.
22] Other mechanisms such as lipotoxicity
 and inflammation  resulting owing to high calorie intake are also likely causes of decline in p-cell functioning.
Role of obesity and lipotoxicity
in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications.