And it was suggested that excess lipid accumulation may lead to lipotoxicity
and may be the major driver of organ dysfunction (Decleves & Sharma, 2015).
Fenofibrate improves renal lipotoxicity
through activation of AMPK-PGC-1[alpha] in db/db mice.
The damage mechanism of lipotoxicity
on microvascular endothelial cells is the increasing production of reactive oxygen species (ROS) caused by the up regulation of the expression level of the NADPH oxidase complex active functional subunit 16.
Beta cell glucose toxicity, lipotoxicity
and chronic oxidative stress in type 2 diabetes.
Insulin resistance, lipotoxicity
, type 2 diabetes and atherosclerosis: the missing links.
High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity
This is called the "thrifty phenotype hypothesis."  And the third is, unfavourable metabolic environment, especially increased glucose levels which may induce glucotoxicity and a persistent increase in NEFA levels that may induce lipotoxicity
.  Gluco-lipotoxicity and the resultant increase in inflammatory mediators are also important.
Heparin has a transient effect in lowering triglyceride levels, it may have potential risk of lipotoxicity
from free fatty acids and increased incidence of bleeding.
Beta-cell glucose toxicity, lipotoxicity
, and chronic oxidative street in type 2 diabetes.
The excess fatty acids interfere with insulin receptor signaling and lead to decreased glucose transport, often referred to as lipotoxicity
. They also activate protein kinase C.
Gilead is advancing multiple novel investigational compounds for the treatment of advanced fibrosis due to NASH, evaluating single-agent and combination therapy approaches against the core pathways associated with NASH hepatocyte lipotoxicity
, inflammation and fibrosis.
The adaptive endoplasmic reticulum stress response to lipotoxicity
in progressive human nonalcoholic fatty liver disease.