liposome


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

liposome

 [lip´o-sōm]
a microscopic spherical particle formed by a lipid bilayer enclosing an aqueous compartment.

lip·o·some

(lip'ō-sōm),
1. A spheric particle of lipid substance suspended in an aqueous medium within a tissue.
2. Any small, roughly spheric artificial vesicle consisting of a lipid bilayer enclosing some of the suspending medium.
[lipo- + G. sōma, body]

liposome

/lipo·some/ (lip´o-sōm) a microscopic spherical particle formed by a lipid bilayer enclosing an aqueous compartment.

liposome

(lĭp′ə-sōm′, lī′pə-)
n.
A microscopic artificial vesicle consisting of an aqueous core enclosed in phospholipid molecules, used to convey vaccines, drugs, or other substances to target tissues.

lip′o·so′mal adj.

liposome

[lip′əsōm]
Etymology: Gk, lipos, fat, soma, body
a small, spheric particle consisting of a bilayer of phospholipid molecules surrounding an aqueous solution.

liposome

Lipid vesicle Drug delivery A synthetic, uniform bilayer lipid membrane-bound vesicle formed by emulsification of cell membranes in dilute salt solutions, which is used to deliver toxic drugs–eg, amphotericin B, doxorubicin, pentavalent antimony–tagging them with an organ-specific antibody. See Liposome-encapsulated amphotericin B, Stealth liposome.

liposome

an artificially constructed PHOSPHOLIPID VESICLE, which can be used in various biological experiments. Certain drugs may be incorporated into liposomes in order to administer them. In this way the drugs may be protected from degradation and may not exert general toxicity when introduced into the bloodstream.

Liposome

Fat molecule made up of layers of lipids.
Mentioned in: Gene Therapy

liposome

a spherical structure, usually multilamelate, prepared from eukaryotic cell membranes which may be used as a carrier for glycoprotein antigens and drugs.
References in periodicals archive ?
The report reviews current pipeline of Taiwan Liposome Company, Ltd.
Product profiles for late stage and clinical stage products of Taiwan Liposome Company, Ltd.
In March 2012, to address the shortage of doxorubicin hydrochloride liposome injection, the FDA announced it would exercise enforcement discretion for temporary controlled importation of doxorubicin hydrochloride liposome injection generic, an alternative to Doxil(R) produced by Taj Phrama India under special authorised manufacturing to maximise the supply other than Janssen Biotech's Doxil(R); enforcement discretion was also used to release one lot of Janssen's Doxil(R) made under an unapproved manufacturing process.
But a new research from University of Southern Denmark has shown that liposomes are not capable of transporting themselves deep into the skin, and thus they are not capable of transporting active ingredients deep into the skin.
Liposome was modified with cetylated polyethylenimine (PEI) to be a non-viral gene transfer system.
Food and Drug Administration (FDA) to partially lift the clinical hold it placed on the Investigational New Drug (IND) application for BLP25 liposome vaccine in March 2010 and allow the START trial to be resumed.
Liposomes can encapsulate and release both hydrophobic and hydrophilic active compounds.
There are five extracts in the current Liposome Herbasec range, which are standardized for specific phytochemicals.
It may be concluded that mannosylated liposome encapsulated QC not only prevented cerebral ischemia and reperfusion induced lipid peroxidation and cerebral edema development but also protected cerebral endogeneous antioxidant defence in young and old rat brain) This approach of delivering a non toxic herbal origin antioxidant (quercetin) to the brain offers the potential clinical application in human degenerative diseases in future)
8,9) The physicochemical properties, such as particle size and surface charges of the liposome DNA complex, may be important factors to obtain a higher transfection efficiency of the liposomal vectors.
Durst, Liposome Flow-Injection Immunoassay--Implications For Sensitivity, Dynamic-Range, And Antibody Regeneration, Anal, Chem.