Effect of Standardizing Radiofrequency Ablation and Lyso-Thermosensitive Liposomal Doxorubicin
(LTLD, ThermoDox) on Overall Survival (OS) Among Patients with a Solitary 3 to 7 cm HCC Lesion: A HEAT Study Multivariate Analysis," by Dr.
is now commercialized in 77 countries for the treatment of advanced soft-tissue sarcoma as single-agent, and in 70 countries for relapsed platinum-sensitive ovarian cancer in combination with pegylated liposomal doxorubicin
TRINOVA-2 is evaluating pegylated liposomal doxorubicin
in combination with either placebo or trebananib in previously treated patients with ovarian cancer while TRINOVA-3, also known as ENGOT -Ov2 and Gynecologic Oncology Group -- 3001, is studying the use of trebananib in front-line treatment adding it to carboplatin/paclitaxel.
bleomycin, vincristine, vinblastine, and an anthracycline (doxorubicin)--have activity in the treatment of KS, but in the developed world, liposomal doxorubicin
and a taxane group constitute the backbone of current systemic chemotherapy against KS.
Starting first with dextrose-essentially sugar water-and later with escalating doses of the same doxorubicin formulation used on Sukumar's rats (pegylated liposomal doxorubicin
, or PLD), she was able to infuse patients' breast ducts via a small catheter placed into the nipple.
When combined with pegylated liposomal doxorubicin
(Doxil/Caelyx), the novel drug brought progression-free survival to 7.
Liposomal agents currently available include liposomal doxorubicin
(Doxil[R], Ortho Biotech Products) and liposomal morphine sulfate (Depodur[R], Endo Pharmaceuticals).
And the second drug, pegulated liposomal doxorubicin
hydroghloride,is also prescribed significantly more often elsewhere,according to the report.
Hycamtin, ovarian cancer, Topotecan, Topoisomerase I inhibitor, recurrent gynecologic malignancies, second line treatment of ovarian cancer, cervical and small cell lung cancer, metastatic ovarian cancer, platinum-sensitive and platinum-resistant, platinum-sensitive patients, antineoplastic agent, torsional strain, sales forecast, phase III/pipeline, competitors to hycamtin gemcitabine liposomal doxorubicin
Avastin paclitaxel carboplatin paclical
When a patient is partially sensitive to platinum, that is the patient relapses within 6 to 12 months after treatment with platinum, among the recommended therapeutic options, oncologists and the most recent ESMO Clinical Practice Guidelines suggest a treatment combining YONDELIS (trabectedin) with pegylated liposomal doxorubicin
followed by a platinum-based therapy.
BEERSE, Belgium, September 30, 2010 /PRNewswire/ -- Marketing rights for CAEYLX(R) (pegylated liposomal doxorubicin
hydrochloride) outside the United States will be transitioned from an affiliate of Merck & Co.
The use of gemcitabine, topotecan, and/or liposomal doxorubicin
in salvage treatment has probably contributed to better survival as well, Dr.