lipoprotein-associated phospholipase 2

lipoprotein-associated phospholipase 2

a protein associated with low-density lipoprotein (LDL) in human serum; expressed by macrophages and present in atherosclerotic lesions. Levels are elevated significantly in patients with coronary artery disease. Oxidized products of Lp-PLA2 are thought to be important factors in development of atherosclerosis because of their ability to attract macrophages and to lead to foam-cell formation.
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[3] Nonstandard abbreviations: Lp-[PLA.sub.2], lipoprotein-associated phospholipase 2; FDA, Food and Drug Administration; MS, mass spectrometry; SISCAPA, stable isotope standards and capture by anti-peptide antibody; FA, formic acid; PAF, Platelet-activating factor; MRM, multiple reaction monitoring; LOQ, limit of quantification; SDS, sodium dodecyl sulfate; apoB, apolipoprotein B; LDL-C, low-density lipoprotein cholesterol; LDL-p, low-density lipoprotein particle number; HDL-C, high-density lipoprotein cholesterol; HDL-p, high-density lipoprotein particle number.
In the Malmo Diet and Cancer cohort, NT-proBNP was evaluated along with CRP, lipoprotein-associated phospholipase 2, midregional proadrenomedullin, and cystatin C (41).