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The concentrations of certain serum lipoproteins correlate closely with the risk of atherosclerosis. Although dietary factors are important in some people with hyperlipidemia, basal levels of lipoprotein, cholesterol, and triglycerides depend chiefly on heredity. Several phenotypes of familial hyperlipoproteinemia associated with risk of premature cardiovascular disease and death have been identified. see hyperlipoproteinemia. An HDL cholesterol level below 35 mg/dL (0.90 mmol/L), an LDL cholesterol level above 160 mg/dL (4.15 mmol/L), and a fasting triglyceride level above 250 mg/dL (2.83 mmol/L) are all independent risk factors for coronary artery disease. Medical management of patients with coronary artery disease (myocardial infarction, angina pectoris, history of coronary artery bypass graft or coronary angioplasty) and other atherosclerotic disorders (peripheral arterial disease, abdominal aortic aneurysm, carotid artery disease) includes detection and correction of hypercholesterolemia and hyperlipoproteinemia. Reducing elevated LDL cholesterol diminishes the risk of coronary artery disease. The currently recommended target serum levels for treatment of disorders of lipid metabolism are LDL cholesterol less than 100 mg/dL (2.6 mmol/L), HDL cholesterol more than 40 mg/dL (1 mmol/L), and triglyceride less than 150 mg/dL (1.7 mmol/L). Dietary recommendations for patients with hyperlipidemia include a total fat intake providing less than 35% of all calories (saturated fat less than 7%, polyunsaturated fat less than 10%, and monounsaturated fat less than 20%), carbohydrate (mostly complex carbohydrates from fruits and vegetables) 50-60% of total calories, fiber 20-30 g/day, and cholesterol less than 200 mg/day. Dietary saturated fat raises LDL cholesterol more than any other dietary component, cholesterol itself not excepted. Of people with elevated LDL cholesterol, 75% can achieve normal levels with diet, weight reduction, and exercise; the others need drug treatment. Factors besides familial hyperlipoproteinemias that can elevate LDL cholesterol include diabetes mellitus, hypothyroidism, nephrotic syndrome, obstructive liver disease, and drugs (progestogens, anabolic steroids, corticosteroids, thiazide diuretics).
lipoprotein(lĭp′ō-prō′tēn′, -tē-ĭn, lī′pō-)
lipoprotein(a)Lp(a) Physiology A lipoprotein with a range of serum levels, a lipid content similar to LDL, which binds to the LDL receptor with lesser affinity than LDL; Lp(a)'s role in ASHD is controversial; it is ↑ in Pts at risk for CAD Ref range 0-30 mg/dL
lipoproteina water-soluble molecule made up of a protein containing a lipid group. It is found, for example, in protoplasm where it is involved in transport of lipids in a soluble form.
Patient discussion about lipoprotein
Q. what are the sources for high density lipoprotein? I have heard that high density lipoprotein is good for heart. What differences does it make in heart’s health and what are the sources for high density lipoprotein?