Lipopolysaccharide-binding protein | definition of lipopolysaccharide-binding protein by Medical dictionary
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lipopolysaccharide-binding protein A trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharide–LPS or to endotoxin–a glycolipid present in the outer membrane of all gram-negative bacteria
One of many acute-phase proteins released into the serum in patients with a gram-negative bacterial infection; it helps to defend the body against sepsis by binding and transferring bacterial endotoxin.
References in periodicals archive
High concentrations of lipopolysaccharide-binding protein
in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes.
Bosmann et al., "Influence of lipopolysaccharide-binding protein
on pulmonary inflammation in gram-negative pneumonia," Shock, vol.
Morey et al., "Lipopolysaccharide-binding protein
and CD14 are increased in the bronchoalveolar lavage fluid of smokers," The European Respiratory Journal, vol.