Kratky, "Cytosolic lipolysis and lipophagy
: two sides of the same coin," Nature Reviews Molecular Cell Biology, vol.
Oh, "The role of macrophage lipophagy
in reverse cholesterol transport," Endocrinology and Metabolism Clinics of North America, vol.
Breakdown of lipid droplets is accomplished by lipophagy
, a specialized form of the intracellular process that degrades cytoplasmic components (i.e., autophagy).
Wang, "Lipid droplets, lipophagy
, and beyond," Biochimica et Biophysica Acta, vol.
In the latter, LDs are incorporated in autophagosomes, which fuse with lysosomes forming autolysosomes, in a process named "lipophagy
Moreover, upon nutrient deprivation, hepatocytes upregulate the transcription of genes related to [beta]-oxidation and autophagy, thus leading to lipophagy
with subsequent [beta]-oxidation and ketone body production [74, 76].
Morittu et al., "Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy
in cafeteria diet-induced rat model of metabolic syndrome," The Journal of Nutritional Biochemistry, vol.
After the entry of virus, there is response of unfolded proteins followed by lipid bodies and lipophagy
, endoplasmic reticulum and autophagy.31 Dengue viral infection of the dendritic cells (DCs) of the skin is main as well as interesting focus point of current research.
(73) A study of hepatocytes demonstrated a "lipophagy
" process, in which LDs are utilized as substrates for autophagy.
is the name for the process of breaking down large quantities of built up fats and reusing them for other purposes.
Most of the recent work on liver autophagy has focused on lipid digestion (lipophagy
) (11,12) and glycogen digestion (13).
A more popular and recent hypothesis suggests a differential effect of lipophagy
, which implies a tissue-selective autophagy with cellular consequences from the mobilisation of intracellular lipids.