lipoic acid


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Related to lipoic acid: Alpha lipoic acid

li·po·ic ac·id

(li-pō'ik as'id),
A bacterial growth factor present in yeast and liver extracts; may be useful in the treatment of mushroom poisoning. Functions as the amide (lipoamide) cofactor in the disulfide (-S-S-) form in the transfer of "active aldehyde" (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form (that is, dihydrolipoic acid) in the process. Lipoic acid is also an essential component of other α-keto acid dehydrogenase complexes.

lipoic acid

/lipo·ic ac·id/ (lip-o´ik) a necessary cofactor for several enzyme complexes involved in the oxidative decarboxylation of keto acids, where it occurs in the form lipoamide. It is used as a dietary supplement for its antioxidant properties.

lipoic acid

(lĭ-pō′ĭk)
n.
An organic acid, C8H14S2O2, that is essential for decarboxylation of pyruvate to acetyl coenzyme A during aerobic metabolism. It is also used as a dietary supplement for its antioxidant properties.

lipoic acid

[lipō′ik]
a bacterial growth factor found in liver and yeast.

lipoic acid

a vitamin prosthetic group in enzymes involved in oxidative decarboxylation of keto acids such as 2-oxoglutarate and pyruvate. Called also α-lipoic acid, thioctic acid.
References in periodicals archive ?
A study of the antioxidant effect of alpha lipoic acids on sperm quality.
After four years, tests showed less severe neuropathy (largely due to less muscular weakness) in the lipoic acid takers, who also reported less weakness but no less pain, burning, or other symptoms.
Novel lipoic acid analogues that inhibit nitric oxide synthase.
Continuous infusion of lipoic acid rapidly reduces plasma beta-hydroxybutyrate with elevation of non esterified fatty acids in broiler chickens.
Efficacy and safety of methylcobalamin, alpha lipoic acid and pregabalin combination versus pregabalin monotherapy in improving pain and nerve conduction velocity in type 2 diabetes associated impaired peripheral neuropathic condition.
Researchers fed laboratory animals higher levels of lipoic acid than might be attained in a normal diet, while monitoring proteins known to be affected by disruption of the circadian clock in the older animals.
Lipoic acid increases de novo synthesis of cellular glutathione by improving crystine utilization.
In addition to Phenibut, comprehensive antioxidant support, including lipoic acid, NAC, taurine, and L-methionine, in conjunction with, vitamins A, C, and E can serve to offset the biochemical effects of both of neurodegenerative diseases and aging.
Alpha lipoic acid finds extensive use as a dietary supplement and as alternative medicine in treatment of diabetes mellitus, mycotoxicosis, hypertension, hyperglycemia, oxidative stress and many other symptoms [1-4].
11 January 2012 - China Nuokang Bio-Pharmaceutical Inc (NASDAQ:NKBP) said today it had agreed to acquire the manufacturing licence and marketing rights for Alpha Lipoic Acid Capsule (ALA), an antioxidant product for the treatment of diabetic neuropathy, from Shandong Qidu Pharmaceutical for CNY18m (USD3m/EUR2.
Lipoic acid is an antioxidant, a compound that blocks the action of free radicals.
Tests using cells from people with Alzheimer's disease (AD), suggest that NAC combined with the antioxidant lipoic acid (see below) may help prevent or reverse oxidative damage associated with mitochondrial dysfunction.