lipoic acid


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Related to lipoic acid: Alpha lipoic acid

li·po·ic ac·id

(li-pō'ik as'id),
A bacterial growth factor present in yeast and liver extracts; may be useful in the treatment of mushroom poisoning. Functions as the amide (lipoamide) cofactor in the disulfide (-S-S-) form in the transfer of "active aldehyde" (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form (that is, dihydrolipoic acid) in the process. Lipoic acid is also an essential component of other α-keto acid dehydrogenase complexes.

lipoic acid

(lĭ-pō′ĭk)
n.
An organic acid, C8H14S2O2, that is essential for decarboxylation of pyruvate to acetyl coenzyme A during aerobic metabolism. It is also used as a dietary supplement for its antioxidant properties.
References in periodicals archive ?
* Many studies now demonstrate that lipoic acid can aid in weight loss, while also reducing inflammation and improving metabolic parameters.
Studies of Farr et al., 2012 [38], have demonstrated that alpha lipoic acid significantly improves reduced glutathione in the mice brain and at the same time decreases lipid peroxidation indicating a reversal of oxidative stress.
Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney.
Researchers (some with industry ties) randomly assigned 456 diabetic neuropathy patients to take 600 milligrams of lipoic acid or a placebo every day.
Lipoic acid is already used in the treatment of degenerative diseases such as multiple sclerosis and diabetic neuropathy.
"This could be a breakthrough in our understanding of why lipoic acid is so important and how it functions," said Tory Hagen, a professor at the Oregon State University in the US, said the study appeared in the journal Biochemical and Biophysical Research Communications.
They include marine collagen which is derived from a substance found on fish scales and is proven to help reduce wrinkles, lycopene, an antioxidant with UV-blocking capabilities, glutathione which helps with cell detoxification and protection and alpha lipoic acid (ALA), which amplifies the positive effects of other important antioxidants in the body.
We recently characterized the role of oxidative stress in the progression of aortic valve calcification (5), while investigating the effects of tempol and lipoic acid (LA).
Reed, "A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes," The Journal of Biological Chemistry, vol.