7] On the one hand, long-term hypertension results in lipohyalinosis
of the media and thickening of the vessel walls, and narrowing of the lumen of the arterioles and small perforating arteries that are derived from cortical and leptomeningeal arteries and nourish the deep WM.
In haemorrhagic stroke, atherosclerosis role is limited; main cause for haemorrhagic stroke is hypertension, lipohyalinosis
, cerebral amyloid angiopathy and fibrinoid necrosis.
Lacunar infarct occurs due to occlusion caused by a microthrombus or lipohyalinosis
in a penetrating artery in the basal ganglia, thalamus, and pons.
However, many white-matter lacunar strokes are considered to be a consequence of small vessel lipohyalinosis
We therefore concluded that plasma Lp(a) is associated with atherothrombotic cardiovascular disease phenotypes and appears to show no association with nonatherosclerotic pathologies such as SAO, which is typically associated with lipohyalinosis
Hypertension increases the likelihood of stroke in several ways: by aggravating atherosclerosis in the aortic arch and cervicocerebral arteries; by causing arteriosclerosis and lipohyalinosis
in the small-diameter, penetrating-end arteries of the cerebrum; and by contributing to heart disease.
Intimal fibroplasia, lipohyalinosis
, and fibrinoid necrosis were absent.
Lacunar infarctions are almost always caused by microvascular disease (either microatheroma or lipohyalinosis
of small penetrating vessels), less commonly by plaques in large arteries that encroach on the orifice of a small vessel.
The SVD subtype, also called lacuna stroke, usually occurs due to the fibrinoid necrosis and lipohyalinosis
of arterioles affected by hypertension-induced pathological processes.
On pathological examination, WMLA are areas of demyelination, gliosis, perivascular oedema, and lipohyalinosis
of the deep penetrating arteries [8, 9].
Microscopic vascular changes in the form of lipohyalinosis
and thickened walls of the white matter arterioles were invariably present but they were seldom totally occluded.