Lipogranuloma or sclerosing lipogranuloma is an unusual benign granulomatous reaction to exogenous or endogenous lipids.
To the best of our knowledge, this report describes the first case of axillary lipogranuloma in a patient with systemic lupus erythematosus (SLE) in the light of mammographic and ultrasonographic findings of this rare entity.
Pathological examination confirmed the diagnosis as lipogranuloma (Figure 3).
Lipogranuloma or sclerosing lipogranuloma is known to be a tissue reaction to exogenous foreign bodies or endogenous lipids, and its etiology has not yet been clearly defined.
Histopathologically, lipogranuloma is characterized by multiple fat vacuoles surrounded by granulomatous tissue composed of multinucleated giant cells, epithelioid histiocytes, and fibrosis.
Based on all these findings, we assumed that the current case was of primary lipogranuloma of the axilla.
The previous reported case of axillary lipogranuloma differed from the current case in that it resulted from a silicone breast implant rupture, and developed in the axillary lymph nodes.
Besides the breast and axilla, the ultrasonographic features of lipogranuloma have been described in the penis and scrotum, and have included cases with an ill-defined area of increased echogenicity in the subcutaneous tissue of the penile shaft, (11) a poorly defined extratesticular echogenic mass with an elongated appearance on a longitudinal scan, (1) and an intratesticular heterogeneously hypoechoic mass.
In conclusion, we present a case of primary axillary lipogranuloma in a patient with SLE for the first time.
Sclerosing lipogranuloma of the scrotum: sonographic findings and pathologic correlation.
Other more uncommon features, such as pseudomyeloproliferative disease, lipogranulomas, and ALIP, were also common to both CVD and control groups.
(%) of cases with: Lymphoid aggregates 10 (40) 16 (42) Pseudo-MPD 0 (0) 1 (3) Abnormal bone 8 (32) 13 (34) Sea-blue histiocytes 4 (16) 1 (3) Lipogranulomas 2 (8) 2 (5) Megaloblastoid erythroid lineage 9 (36) 10 (26) ALIP 7 (28) 5 (13) All Other CVDs Controls Total No.