Un estudio describio que la fructosa podria contribuir a la obesidad al estimular la proteina de union al elemento receptor de esterol 1c (SREBP-1c) independiente de la insulina, que activa los genes involucrados en lipogenesis
de novo (Matsuzaka et al., 2004) y genera acidos grasos para la produccion de trigliceridos en el higado.
Adipose tissue regulates insulin sensitivity: Role of adipogenesis, de novo lipogenesis
and novel lipids.
In this study, we identified the factors associated with de novo lipogenesis
after culturing HepG2 cells with: (1) high fructose, (2) high fructose followed by the ERS inhibitor tauroursodeoxycholic acid (TUDCA), or (3) the ERS inducer thapsigargin.
Pathways to Inflammation in Acne Pathogenesis Hormonal initiators in acne include elevated insulin, IGF-1, and androgen levels.These lead to disinhibition of FoxOl and activation of mTORCl, resulting in increased local pilosebaceous androgenesis, lipogenesis
, and increased squalene, fatty acid production, and desaturation.
Although unsubstantiated, one may argue that RT can induce activation of AMPK by decreasing the expression of transcription factors related to lipogenesis
, increasing the oxidation of fat in the liver, and ultimately reducing the fat content in the liver as discussed previously by Lavoie et al.
These changes might have originated from both the dietary intervention and de novo lipogenesis
. The characteristic feature of the profile of fatty acids of EM was the reduction of the content of all saturated acids (Table 5), which might have been associated with the significant elimination of food sources of these acids among patients following the diet.
List et al., "Growth hormone inhibits hepatic de novo lipogenesis
in adult mice," Diabetes, vol.
Lipid deposition can occur by uptake of circulating FA (in a higher extent) and lipogenesis
de novo from nonlipid precursors.
This suggests that it may have a smaller contribution to glucose homeostasis than GLP-1, although it may have a greater role in lipogenesis
Insulin promotes lipogenesis
by increasing NEFA uptake by the adipose tissues ; however, GH has the opposite action .
Durante muchas decadas se considero al tejido adiposo como un deposito inerte de trigliceridos, con una unica funcion de participar en la regulacion de la utilizacion de estas reservas energeticas por el organismo, via lipogenesis
ACC catalyzes the first step in hepatic de novo lipogenesis
, the synthesis of fatty acids that contribute to hepatic steatosis and, subsequently, inflammation and liver fibrosis.