lipofuscin


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lipofuscin

 [lip″o-fu´sin]
1. a yellow to brown, granular, iron-negative lipid pigment found particularly in muscle, heart, liver, and nerve cells; it is the product of cellular wear and tear, accumulating in lysosomes with age.

lip·o·fus·cin

(lip'ō-fyūs'in),
Brown pigment granules representing lipid-containing residues of lysosomal digestion and considered one of the aging or "wear and tear" pigments; found in liver, kidney, heart muscle, adrenal, and ganglion cells.

lipofuscin

/lipo·fus·cin/ (-fu´sin) any of a class of fatty pigments formed by the solution of a pigment in fat.

lipofuscin

(lĭp′ō-fŭs′ĭn, -fyo͞o′sĭn)
n.
A lipid-containing brownish-yellow pigment that occurs in granules especially in senescent cells.

lipofuscin

[lip′əfus′in]
a class of fatty pigments consisting mostly of oxidized fats that are found in abundance in the cells of adults. Lipofuscins accumulate in lysosomes with age.

lipofuscin

A pigmented lipid degradation product thought to derive from peroxidative destruction of mitochondrial polyunsaturated lipid membrane or the mitochondrion itself; the malonaldehyde produced by mitochondrial peroxide damage may block DNA template, activity contributing to heart failure; lipofuscin accumulates with age in the heart, muscle, liver, nerve, and in lysosomes

lip·o·fus·cin

(lip'ō-fyūs'in)
Brown pigment granules representing lipid-containing residues of lysosomal digestion and considered one of the aging or "wear-and-tear" pigments; found in liver, kidney, heart muscle, and ganglion cells.

lipofuscin

A golden-brown pigment that occurs in granules in muscle and nerve cells in numbers proportional to the age of the individual. Also known as age pigment.

lipofuscin (līˈ·pō·fyōōˑ·sin),

n brown-colored pigment characteristic of aging. Found in liposomes and prod-uct of peroxidation of unsaturated fatty acids.

lipofuscin

Yellowish-brown pigment granules formed as a result of oxidation of protein and lipid residues, and found in various tissues (e.g. liver, kidney, heart muscle, adrenals, nerve cells). It normally accumulates with age within the lysosomes of cells and its accumulation in the retinal pigment epithelium (RPE) is a major risk factor of age-related macular degeneration as it may damage RPE cells and lead to the formation of drusen and RPE atrophy. In albinos the pigment granules are immature and colourless.

lipofuscin

any of a class of fatty pigments formed by the solution of a pigment in fat. They take the form of golden granular deposits derived from lipid components of membranous organelles, and commonly occur with advancing age or vitamin E deficiency. Called also abnutzen pigment.

lipofuscin-like pigment
accumulates in the liver of patients, e.g. mutant Corriedale sheep, which lack enzymes necessary for bile salt conjugation and transport; the livers of affected sheep are black.
References in periodicals archive ?
Use of extractable lipofuscin to estimate age structure of ghost shrimp populations in west coast estuaries of the USA.
The material guarantees cell and tissue longevity and blocks the accumulation of lipofuscin aggregates, according to Silab.
1,2,3,25-32) Additionally, fat is discolored yellow or red-brown because of the deposition of ceroid or lipofuscin pigment within adipose cells.
Additional hepatic lesions analyzed as binary variables included steatosis, inflammation, Kupffer cell hyperplasia, oval cell hyperplasia, multinucleated hepatocytes, hepatocyte hypertrophy, and lipofuscin deposition.
3] lipofuscin pigment4 and melanotic renal cell carcinoma (RCC); all cases are very rare.
Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following vitamin A supplementation.
The etiology of AMD is not fully understood, but it appears to involve accumulation of lipofuscin within retinal cells as a result of ultraviolet light- or oxygen-induced free-radical damage to cell membranes.
Lipofuscin in the cortical brain is elevated, which is a marker of oxidative tissue damage.
Blue-gray discoloration of the skin is an uncommon side effect caused by the ultraviolet accumulation of lipofuscin in dermal macrophages.
Zeaxanthin is thought to be more effective than all antioxidants, including vitamin E, at inhibiting lipofuscin, which accumulates in the retina with age and is associated with vision loss.
Lipofuscin autofluorescence: evidence for vitamin A involvement in the retina.