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1. a yellow to brown, granular, iron-negative lipid pigment found particularly in muscle, heart, liver, and nerve cells; it is the product of cellular wear and tear, accumulating in lysosomes with age.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Brown pigment granules representing lipid-containing residues of lysosomal digestion and considered one of the aging or "wear and tear" pigments; found in liver, kidney, heart muscle, adrenal, and ganglion cells.
Farlex Partner Medical Dictionary © Farlex 2012
A lipid-containing brownish-yellow pigment that occurs in granules especially in senescent cells.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
lipofuscinA pigmented lipid degradation product thought to derive from peroxidative destruction of mitochondrial polyunsaturated lipid membrane or the mitochondrion itself; the malonaldehyde produced by mitochondrial peroxide damage may block DNA template, activity contributing to heart failure; lipofuscin accumulates with age in the heart, muscle, liver, nerve, and in lysosomes
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
Brown pigment granules representing lipid-containing residues of lysosomal digestion and considered one of the aging or "wear-and-tear" pigments; found in liver, kidney, heart muscle, and ganglion cells.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
lipofuscinA golden-brown pigment that occurs in granules in muscle and nerve cells in numbers proportional to the age of the individual. Also known as age pigment.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
Yellowish-brown pigment granules formed as a result of oxidation of protein and lipid residues, and found in various tissues (e.g. liver, kidney, heart muscle, adrenals, nerve cells). It normally accumulates with age within the lysosomes of cells and its accumulation in the retinal pigment epithelium (RPE) is a major risk factor of age-related macular degeneration as it may damage RPE cells and lead to the formation of drusen and RPE atrophy. In albinos the pigment granules are immature and colourless.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann