lipofuscin


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lipofuscin

 [lip″o-fu´sin]
1. a yellow to brown, granular, iron-negative lipid pigment found particularly in muscle, heart, liver, and nerve cells; it is the product of cellular wear and tear, accumulating in lysosomes with age.

lip·o·fus·cin

(lip'ō-fyūs'in),
Brown pigment granules representing lipid-containing residues of lysosomal digestion and considered one of the aging or "wear and tear" pigments; found in liver, kidney, heart muscle, adrenal, and ganglion cells.

lipofuscin

/lipo·fus·cin/ (-fu´sin) any of a class of fatty pigments formed by the solution of a pigment in fat.

lipofuscin

(lĭp′ō-fŭs′ĭn, -fyo͞o′sĭn)
n.
A lipid-containing brownish-yellow pigment that occurs in granules especially in senescent cells.

lipofuscin

[lip′əfus′in]
a class of fatty pigments consisting mostly of oxidized fats that are found in abundance in the cells of adults. Lipofuscins accumulate in lysosomes with age.

lipofuscin

A pigmented lipid degradation product thought to derive from peroxidative destruction of mitochondrial polyunsaturated lipid membrane or the mitochondrion itself; the malonaldehyde produced by mitochondrial peroxide damage may block DNA template, activity contributing to heart failure; lipofuscin accumulates with age in the heart, muscle, liver, nerve, and in lysosomes

lip·o·fus·cin

(lip'ō-fyūs'in)
Brown pigment granules representing lipid-containing residues of lysosomal digestion and considered one of the aging or "wear-and-tear" pigments; found in liver, kidney, heart muscle, and ganglion cells.

lipofuscin

A golden-brown pigment that occurs in granules in muscle and nerve cells in numbers proportional to the age of the individual. Also known as age pigment.

lipofuscin (līˈ·pō·fyōōˑ·sin),

n brown-colored pigment characteristic of aging. Found in liposomes and prod-uct of peroxidation of unsaturated fatty acids.

lipofuscin

Yellowish-brown pigment granules formed as a result of oxidation of protein and lipid residues, and found in various tissues (e.g. liver, kidney, heart muscle, adrenals, nerve cells). It normally accumulates with age within the lysosomes of cells and its accumulation in the retinal pigment epithelium (RPE) is a major risk factor of age-related macular degeneration as it may damage RPE cells and lead to the formation of drusen and RPE atrophy. In albinos the pigment granules are immature and colourless.

lipofuscin

any of a class of fatty pigments formed by the solution of a pigment in fat. They take the form of golden granular deposits derived from lipid components of membranous organelles, and commonly occur with advancing age or vitamin E deficiency. Called also abnutzen pigment.

lipofuscin-like pigment
accumulates in the liver of patients, e.g. mutant Corriedale sheep, which lack enzymes necessary for bile salt conjugation and transport; the livers of affected sheep are black.
References in periodicals archive ?
So far the attempt was to keep lipofuscin levels the same but remofuscin has been shown to actually remove existing lipofuscin in pre-clinical models and this may result in significant patient benefit.
Pulmonary involvement in HPS is characterized by accumulation of ceroid lipofuscin within the lung, manifested by the presence of clear, vacuolated, ceroid-laden type 2 pneumocytes and alveolar macrophages (Figure 7, B through D) that are typically found in a background of prominent interstitial fibrosis.
This autofluorescence (AF), which comes from N-retinyliden-N-retinylethanolamin (A2-E) found in lipofuscin granules in the retinal pigment epithelium, can be easily visualized using a fundus camera or a confocal scanning laser microscope modified with AF filters.
It forms large aggregates and increases in size after active phagocytosis of heterogeneous materials such as detritus, melanin (brown or black color), ceroid or hemosiderin and lipofuscin (natural yellowish color or blue) (AGIUS, 1980; MUNSHI & DUTTA, 1996).
Age determination studies on these invertebrates have to concentrate on techniques that do not use hard parts, including tag- recapture studies, modal analysis of length distribution data, raising animals under laboratory conditions, and quantifying lipofuscin accumulation in nerve tissue (Shinozaki-Mendes et al.
The blue portion of the visible spectrum of light (441 nm) is dangerous for RPE cells, since it is the most energetic radiation reaching the macula and because it promotes photooxidation of lipofuscin generating the reactive photoproducts including N-retinylidene-N-retinylethanolamine (A2E), DNA oxidation, and cells apoptosis [189, 190].
However, during the operation, we observed severe black colouration of the knee articular cartilage, due to the deposition of hemosiderin and lipofuscin after the recurrent haemarthrosis.
Significantly higher fractions of lipofuscin, an insoluble lipid peroxidation byproduct that can be related to contaminant exposure, in kidney diverticula of the coal-exposed mussels suggested that unidentified contaminants were present in the water.
Hemosiderin, lipofuscin, minocycline itself or its quinone by-product, have also been suggested since the presence of minocycline crystals has been demonstrated in up to 32% of localised pigmentation.
Fine needle aspiration cytology of retroperitoneal paraganglioma with lipofuscin pigmentation.
The material guarantees cell and tissue longevity and blocks the accumulation of lipofuscin aggregates, according to Silab.
Lipofuscin, an aggregate of peroxidized lipids and proteins accumulates in lysosomes of aged cells and brain cells of patients with Alzheimer's disease [15].