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1. a yellow to brown, granular, iron-negative lipid pigment found particularly in muscle, heart, liver, and nerve cells; it is the product of cellular wear and tear, accumulating in lysosomes with age.
Brown pigment granules representing lipid-containing residues of lysosomal digestion and considered one of the aging or "wear and tear" pigments; found in liver, kidney, heart muscle, adrenal, and ganglion cells.
A lipid-containing brownish-yellow pigment that occurs in granules especially in senescent cells.
lipofuscinA pigmented lipid degradation product thought to derive from peroxidative destruction of mitochondrial polyunsaturated lipid membrane or the mitochondrion itself; the malonaldehyde produced by mitochondrial peroxide damage may block DNA template, activity contributing to heart failure; lipofuscin accumulates with age in the heart, muscle, liver, nerve, and in lysosomes
Brown pigment granules representing lipid-containing residues of lysosomal digestion and considered one of the aging or "wear-and-tear" pigments; found in liver, kidney, heart muscle, and ganglion cells.
lipofuscinA golden-brown pigment that occurs in granules in muscle and nerve cells in numbers proportional to the age of the individual. Also known as age pigment.
Yellowish-brown pigment granules formed as a result of oxidation of protein and lipid residues, and found in various tissues (e.g. liver, kidney, heart muscle, adrenals, nerve cells). It normally accumulates with age within the lysosomes of cells and its accumulation in the retinal pigment epithelium (RPE) is a major risk factor of age-related macular degeneration as it may damage RPE cells and lead to the formation of drusen and RPE atrophy. In albinos the pigment granules are immature and colourless.