A mixture predominantly of phospholipids used for aiding in the transfer of DNA into cells.
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Plasmids were transiently transfected into the cells using Lipofectin Reagent (GibcoBRL).
The evaluation, which was conducted in collaboration with Triplex Pharmaceuticals, compared cellular uptake and internalization of Zyn-Linker- oligonucleotide conjugates to unmodified oligonucleotides delivered using Lipofectin, a commercially available lipid vehicle.