lipodystrophy


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Related to lipodystrophy: lipodystrophy syndrome

lipodystrophy

 [lip″o-dis´tro-fe]
1. any disturbance of fat metabolism.
2. a group of conditions due to defective metabolism of fat, resulting in absence of subcutaneous fat; they may be congenital or acquired and partial or total. (See Atlas 2, Part F.)
congenital generalized lipodystrophy an autosomal recessive condition marked by the virtual absence of subcutaneous adipose tissue, large body size, splenomegaly, hirsutism, acanthosis nigricans, and reduced glucose tolerance in the presence of high insulin levels.
intestinal lipodystrophy former name for Whipple's disease.
partial lipodystrophy a condition seen mainly in females in the first decade of life, characterized by symmetrical loss of subcutaneous fat, usually beginning on the face and gradually extending to the chest, neck, back, and upper limbs; this gives the lower part of the body an apparent, and possibly real, adiposity of the buttocks and lower limbs. Some affected patients develop insulin-resistant diabetes mellitus, triglyceridemia, and renal disease.
progressive lipodystrophy progressive and symmetrical loss of subcutaneous fat from the parts above the pelvis, facial emaciation, and abnormal accumulation of fat about the thighs and buttocks.
total lipodystrophy an autosomal recessive disorder occurring mainly in females, characterized by a generalized loss of subcutaneous fat and extracutaneous adipose tissue, present at birth or appearing later in life, and associated with hepatomegaly with abdominal protuberance, hypoglycemia and insulin-resistant nonketotic diabetes, hyperlipemia, marked elevation of the basal metabolic rate, accelerated somatic growth, advanced bone age, acanthosis nigricans and hirsutism.

lip·o·dys·tro·phy

(lip'ō-dis'trō-fē),
1. Defective metabolism of fat.
2. Abnormal depositions or wastings of adipose tissue, or combinations of these changes, seen in consequence of some protease inhibitor use in AIDS patients.
Synonym(s): cellulite (2) , lipodystrophia
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]

lip·o·dys·tro·phy

(lip'ō-dis'trŏ-fē)
Defective metabolism of fat.
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]

lipodystrophy

A condition of disordered fat metabolism. There may be abnormal breakdown of fats with loss of weight, excessive levels of fats in the blood, raised blood sugar levels, enlargement of the liver and abnormal thyroid gland function. In some cases there is breakdown of fat from the upper part of the body and abnormal deposition around the buttocks and thighs. The condition can be caused by prolonged multiple antiretoviral therapy.

lip·o·dys·tro·phy

(lip'ō-dis'trŏ-fē)
1. Defective metabolism of fat.
2. Abnormal depositions or wastings of adipose tissue, or combinations of these changes.
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]
References in periodicals archive ?
To this day theres is no precise definition of what exactly woman lipodystrophy, commonly known as cellulite, is: an illness or just cosmetic defect?
studied the effect of BSCL2 gene deletion in fully differentiated mouse adipose tissue and found a progressive lipodystrophy. As expected, signals of TG accumulation were observed together with lipolysis impairment [74].
One of them was extracting all the necessary data based on the questionnaire and the second nurse was performing the visual inspection and palpation of injection sites to detect lipodystrophy. This type of data collection technique was intentionally applied to reduce bias that would happen if a single data collector was involved in both activities.
In the present study, lipodystrophy patients exhibited different patterns of adipose tissue loss.
Generalized lipodystrophy, acanthosis nigricans, muscular hypertrophy, hepatomegaly, insulin resistance, and hypertriglyceridemia were features present in all three patients.
Prevalence of Lipodystrophy. Prevalence of lipodystrophy was 20.4% with primary lipoatrophy (49.5%) being the most prevalent form of lipodystrophy followed by mixed lipodystrophy (37.9%) and primary lipohypertrophy (12.6%) was the least common (Table 1).
Wanke, Epidemiology, Clinical Manifestations, and Diagnosis of HIV-Associated Lipodystrophy. UpToDate, Walters Kluwer Health, Waltham, Mass, USA, 2016.
"Our patient did have very, very subtle lipodystrophy, but overall not as quick onset as some other [cases in children] that have been described," Dr.
In 2014, GLAD began lobbying for a bill to get treatments for lipodystrophy covered by insurance companies as a mandate in Massachusetts, the first bill of its kind to be introduced in state legislatures.
(17,18) The combination of negative effects on physical and mental function in HIV-infected patients with lipodystrophy may have a further adverse impact on HRQOL, but its impact on aerobic capacity and quality of life has not been properly studied.
This report provides comprehensive information on the therapeutic development for Lipodystrophy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.