Lipocortin | definition of lipocortin by Medical dictionary
Also found in: Acronyms
Corticosteroid-induced inhibitor of phospholipase A2. It inhibits formation of arachidonic acid and is considered a mediator of the antiinflammatory action of corticosteroids.
annexin A generic term for a large (160 +) family of calcium- and phospholipid-binding proteins and phospholipase A2- and blood coagulation inhibitors, which interact with acidic membrane phospholipids in cell membranes.
References in periodicals archive
1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line," Proceedings of the National Academy of Sciences of the United States of America, vol.
Mukherjee, "Novel anti-inflammatory peptides from the region of highest similarity between uteroglobin and lipocortin
I," Nature, vol.
and mechanism of action of the glucocorticoids.
The underlying mechanism concerns induction of mRNA and protein expression of lipocortin
1 (annexin 1) and the PL[A.sub.2] inhibitory protein [101-104].