lipocalin


Also found in: Wikipedia.

lipocalin

Any of a ubiquitous (found in plants, gram-negative bacteria, invertebrates and vertebrates) superfamily of carrier proteins, which share regions of sequence homology and a common tertiary structure: an eight-stranded, antiparallel, symmetrical beta-barrel fold (in essence, a beta sheet rolled into a cylinder enclosing an internal ligand binding site). Lipocalins transport small hydrophobic molecules (e.g., steroids, bilins, retinoids and lipids) and are associated with various biological processes, including immune response, pheromone transport, prostaglandin synthesis, retinoid binding and cancer cell interactions.

Human lipocalins
Alpha-1-microglobulin, alpha-1-acid glycoprotein (orosomucoid), aphrodisin, apolipoprotein D, beta-lactoglobulin, complement component C8 gamma chain, epididymal-retinoic acid binding protein, human pregnancy-associated endometrial alpha-2 globulin, probasin (a prostatic protein), prostaglandin D synthase.
References in periodicals archive ?
BioPorto A/S (CPH: BIOPOR), an in-vitro diagnostics company, announced on Friday that it has entered into a global distribution agreement with Roche (VTX:ROG), under which BioPorto will deliver a neutrophil gelatinase-associated lipocalin (NGAL) test for use on Roche's cobas c 501/c 502 analysers.
Ma et al (88) showed increased expression of PTC-associated markers, such as neutrophil gelatinase-associated lipocalin, CK19, and claudin 1, in foci of atypical follicular epithelium compared with peritumoral benign thyroid tissue, whereas Prasad et al (89) identified the expression of HBME-1, galectin-3, CK19, CITED1, and fibronectin in PTC-like nuclear alterations of CLT.
Acase-control study of pre-operative levels of serum neutrophil gelatinase-associated lipocalin and other potential inflammatory markers in colorectal cancer.
Recombinant human lipocalin 2 acts as an antibacterial agent to prevent platelet contamination.
Adipose-derived lipocalin 14 alleviates hyperglycaemia by suppressing both adipocyte glycerol efflux and hepatic gluconeogenesis in mice.
Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease.
The IL1B also increases the expression of many endometrial genes, including IL1B receptor genes IL1 receptor 1 (IL1R1) and IL1RAP, PG transporter genes ABCC4 and SLCO2A1, a calcium binding protein gene S100 calcium binding protein G (S100G), and a small lipid binding protein gene salivary lipocalin 1 (SAL1) [8,28].
Thus, BAT was shown to release factors such as IGF-1, fibroblast growth factor-2, IL-1[alpha], IL-6, bone morphogenetic protein-8b, and lipocalin prostaglandin D synthase that primarily have autocrine or paracrine actions (Villarroya et al.
Pentraxin-3 (PTX-3) and neutrophil gelatinase-associated lipocalin (NGAL) are believed to be involved in the pathophysiology of ACS (10).
9) found that neutrophil gelatinase-associated lipocalin and lactroferrin were significantly higher in ANCA-negative patients than in ANCA-positive ones.
Preliminary evidence suggests a potential prognostic role of serum neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (29).
Ademas de la sobreproduccion de hepcidina hay que tener en cuenta el lipocalin, por cuanto ambos conducen a un secuestro del hierro en el sistema reticuloendotelial (35).