lipocalin


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lipocalin

Any of a ubiquitous (found in plants, gram-negative bacteria, invertebrates and vertebrates) superfamily of carrier proteins, which share regions of sequence homology and a common tertiary structure: an eight-stranded, antiparallel, symmetrical beta-barrel fold (in essence, a beta sheet rolled into a cylinder enclosing an internal ligand binding site). Lipocalins transport small hydrophobic molecules (e.g., steroids, bilins, retinoids and lipids) and are associated with various biological processes, including immune response, pheromone transport, prostaglandin synthesis, retinoid binding and cancer cell interactions.

Human lipocalins
Alpha-1-microglobulin, alpha-1-acid glycoprotein (orosomucoid), aphrodisin, apolipoprotein D, beta-lactoglobulin, complement component C8 gamma chain, epididymal-retinoic acid binding protein, human pregnancy-associated endometrial alpha-2 globulin, probasin (a prostatic protein), prostaglandin D synthase.
References in periodicals archive ?
com)-- Epitope Diagnostics is proud to add Neutrophil Gelatinase-associated Lipocalin (NGAL) ELISA kit to its growing fecal test panel.
In addition, tear fluid also contains antimicrobial compounds, particularly a protein called lipocalin, which tightly binds to compounds secreted by bacteria and scavenges foreign oily materials that could otherwise damage the cornea.
Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation.
Several novel biomarkers have been suggested to improve the early diagnosis of AKI, including interleukin-18, neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1.
Lipocalin2 also known as neutrophil gelatinase associated lipocalin, sidrocalin and 24p3, is another member of the lipocalin family recently reported to have possible metabolic roles [7].
We have previously demonstrated that the expression of mucin-4 (MUC4), mucin-16 (MUC16), and neutrophil gelatinase-associated lipocalin (NGAL) is not expressed by the normal pancreatic ducts but is aberrantly expressed in the malignant ducts.
They concluded that the biomarkers currently showing most promise, in terms of risk stratification, were Lp-PLA2 (inflammation), neutrophil gelatinase-associated lipocalin and cystatin C (both renal stress), procollagen-1-polypeptide (extracellular matrix remodelling), brain natriuretic peptide, NT-proBNP MR-proADM, soluble ST2 receptor and copeptin (all cardiac myocyte stress), and endothelin 1 (neurohormone regulation).
Studies have revealed that smokers have higher levels of myeloperoxidase, human neutrophil lipocalin, eosinophil cationic protein, and lysozyme in their blood.
These remain our renal biomarkers of choice until the use of newer renal biomarkers, such as neutrophil gelatinase associated lipocalin and cystatin C, becomes commonplace.
C8[gamma] is structurally unrelated to any complement protein; it is a member of the lipocalin family of proteins that have the common ability to bind small hydrophobic ligands, e.
A variety of other alterations have been described in A-ASCs exposed to the magnetic fields in MRIs, including up-regulation of CD93 mRNA, lipocalin 6 mRNA, sialic acid acetylesterase mRNA, and olfactory receptor mRNA, and down-regulation of ubiquilin 1 mRNA.