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Loss of subcutaneous fat, which may be total, congenital, and associated with hepatomegaly, excessive bone growth, and insulin-resistant diabetes.
[G. lipos, fat, + a-, priv. + trophē, nourishment]
an inherited disease characterized by a total loss of subcutaneous body fat, insulin-resistant diabetes mellitus, acanthosis nigricans, hypermetabolism, hepatomegaly, and hypertrophied musculature. It is associated with a disorder of the hypothalamus that results in excessive blood levels of growth hormone and adrenocorticotropic-releasing hormones. Also called congenital total lipodystrophy.
lipoatrophic diabetes(1) Lipodystrophy, see there.
(2) Familial partial lipodystrophy, see there.