LPIN1

(redirected from lipin-1)

LPIN1

A gene on chromosome 2p25.1 that encodes a magnesium-dependent phosphatidate phosphatase, which:
(1) Converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum;
(2) Is a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression;
(3) Is involved in adipocyte differentiation; and which
(4) May be involved in mitochondrial fission, converting phosphatidic acid to diacylglycerol.

Molecular pathology
LPIN1 mutations may cause lipodystrophy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
More in detail, mTORC1 phosphorylates LIPIN-1 and prevents it from entering the nucleus, resulting in the suppression of the sterol regulatory element-binding protein 1/2 (SREBP1/2), a transcription factor involved in fatty acid and cholesterol synthesis [11] (Figure 1(c)).
Reue, "Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes," The Journal of Biological Chemistry, vol.
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL.
Lipin-1 lowers SREBP1/2 levels inside the nucleus and mTORC1 mediated phosphorylation of Lipin-1 prevents it from entering the nucleus, thus suppressing this inhibition [119].
Moreover, Ppard interaction with hepatic AMPK (phospho-AMP-activated protein kinase), PGC-1a (PPAR[alpha]PPAR[gamma] coactivator), and lipin-1 refers to them as therapeutic targets in the prevention of dyslipidemia [51].
Chronic feeding of mice with an ethanol liquid diet downregulates the activity of the HDAC SIRT-1 and increases the expression of lipin-1, an important regulator of lipid synthesis in the liver (Yin et al.
Mutations in the Lipin-1 gene, the PA phosphatase that generates DAG from PA, have been associated with metabolic and neurological diseases [35].
Alternatively, PA may be converted to DAG, which is a substrate for the synthesis of PE and PC, in a reaction catalysed by PA phosphatases such as Lipin-1 [35, 91].