LPIN1

(redirected from lipin-1)

LPIN1

A gene on chromosome 2p25.1 that encodes a magnesium-dependent phosphatidate phosphatase, which:
(1) Converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum;
(2) Is a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression;
(3) Is involved in adipocyte differentiation; and which
(4) May be involved in mitochondrial fission, converting phosphatidic acid to diacylglycerol.

Molecular pathology
LPIN1 mutations may cause lipodystrophy.
References in periodicals archive ?
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Chronic feeding of mice with an ethanol liquid diet downregulates the activity of the HDAC SIRT-1 and increases the expression of lipin-1, an important regulator of lipid synthesis in the liver (Yin et al.