More in detail, mTORC1 phosphorylates LIPIN-1
and prevents it from entering the nucleus, resulting in the suppression of the sterol regulatory element-binding protein 1/2 (SREBP1/2), a transcription factor involved in fatty acid and cholesterol synthesis  (Figure 1(c)).
Reue, "Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1
in adipocytes," The Journal of Biological Chemistry, vol.
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL.
lowers SREBP1/2 levels inside the nucleus and mTORC1 mediated phosphorylation of Lipin-1
prevents it from entering the nucleus, thus suppressing this inhibition .
Moreover, Ppard interaction with hepatic AMPK (phospho-AMP-activated protein kinase), PGC-1a (PPAR[alpha]PPAR[gamma] coactivator), and lipin-1
refers to them as therapeutic targets in the prevention of dyslipidemia .
Chronic feeding of mice with an ethanol liquid diet downregulates the activity of the HDAC SIRT-1 and increases the expression of lipin-1
, an important regulator of lipid synthesis in the liver (Yin et al.
Mutations in the Lipin-1 gene, the PA phosphatase that generates DAG from PA, have been associated with metabolic and neurological diseases .
Alternatively, PA may be converted to DAG, which is a substrate for the synthesis of PE and PC, in a reaction catalysed by PA phosphatases such as Lipin-1 [35, 91].