LPIN2

(redirected from lipin 2)

LPIN2

A gene on chromosome 18p11.31 that encodes a magnesium-dependent phosphatidate phosphatase, which converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum, and which acts a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression.

Molecular pathology
LPIN2 mutations may cause lipodystrophy.
References in periodicals archive ?
Lipin 2 is a liverenriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
Se describio un sindrome autosomico recesivo llamado sindrome de Majeed que cursa con OCMR y es dado por la mutacion en el gen LIPIN 2 (3, 4, 5).