LPIN2

(redirected from lipin 2)

LPIN2

A gene on chromosome 18p11.31 that encodes a magnesium-dependent phosphatidate phosphatase, which converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum, and which acts a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression.

Molecular pathology
LPIN2 mutations may cause lipodystrophy.
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References in periodicals archive ?
Lipin 2 is a liverenriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
The disease is caused by homozygous mutations in the LPIN2 gene (Table 1) encoding for lipin 2, the role of which has not yet been clarified [143].