Many other SNPs of different genes involved in lipid metabolism, such as lipin 1
(LPIN1), oxidative stress, such as superoxide dismutase 2 (SOD2), and fibrogenesis, such as Kruppel-like factor 6 (KLF6), have been associated with the severity of liver damage in different studies on NAFLD patients [8-12].
Harris et al., "mTOR complex 1 regulates lipin 1
localization to control the SREBP pathway," Cell, vol.
Rochford, "Seipin oligomers can interact directly with AGPAT2 and lipin 1
, physically scaffolding critical regulators of adipogenesis," Molecular Metabolism, vol.
Gene Symbol Description FC DLAT Dihydrolipoamide -1,678 S-acetyltransferase HSPB7 Heat shock protein family B -1,422 (small) member 7 LPIN1 Lipin 1
-1,838 MECP2 Methyl-CpG binding protein 2 -1,22 NDUFS3 NADH: ubiquinone oxidoreductase -1,314 core subunit S3 NT5C 5', 3'-nucleotidase, cytosolic -1,524 SIRT5 Sirtuin 5 -1,255 YWHAQ Tyrosine 3-monooxygenase/tryptophan -1,364 5-monooxygenase activation protein theta
Zheng et al., "Troxerutin improves hepatic lipid homeostasis by restoring NAD+-depletion-mediated dysfunction of lipin 1
signaling in high-fat diet-treated mice," Biochemical Pharmacology, vol.
Interestingly, lipin 1
(LPIN1) was recognized to be the member of both downregulated transcription-regulating GO (regulation of transcription, DNA-dependent) and downregulated metabolic pathways.
Temporal and spatial regulation of the phosphatidate phosphatases lipin 1
(15) It has been shown that HIF-mediated stimulation of lipin 1
expression causes triglyceride accumulation.
is an inducible amplifier of the hepatic PGC-1 alpha/PPARalpha regulatory pathway.
Chen et al., "Lipin 1
is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway," Cell Metabolism, vol.
LPIN1 (lipin 1
) and GAMT (guanidinoacetate N-methyltransferase) expression levels are subjected to p53-dependent increase [144, 145].
The activation of PPAR[alpha] by Wy-14643 resulted in a general increase in lipid metabolism-related genes including several involved in lipid synthesis, such as lipin 1
(LPIN1) and sterol regulatory element binding transcription factor 1 (SREBF1) .