LPIN1

(redirected from lipin 1)

LPIN1

A gene on chromosome 2p25.1 that encodes a magnesium-dependent phosphatidate phosphatase, which:
(1) Converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum;
(2) Is a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression;
(3) Is involved in adipocyte differentiation; and which
(4) May be involved in mitochondrial fission, converting phosphatidic acid to diacylglycerol.

Molecular pathology
LPIN1 mutations may cause lipodystrophy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Many other SNPs of different genes involved in lipid metabolism, such as lipin 1 (LPIN1), oxidative stress, such as superoxide dismutase 2 (SOD2), and fibrogenesis, such as Kruppel-like factor 6 (KLF6), have been associated with the severity of liver damage in different studies on NAFLD patients [8-12].
Harris et al., "mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway," Cell, vol.
Rochford, "Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis," Molecular Metabolism, vol.
Gene Symbol Description FC DLAT Dihydrolipoamide -1,678 S-acetyltransferase HSPB7 Heat shock protein family B -1,422 (small) member 7 LPIN1 Lipin 1 -1,838 MECP2 Methyl-CpG binding protein 2 -1,22 NDUFS3 NADH: ubiquinone oxidoreductase -1,314 core subunit S3 NT5C 5', 3'-nucleotidase, cytosolic -1,524 SIRT5 Sirtuin 5 -1,255 YWHAQ Tyrosine 3-monooxygenase/tryptophan -1,364 5-monooxygenase activation protein theta
Zheng et al., "Troxerutin improves hepatic lipid homeostasis by restoring NAD+-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice," Biochemical Pharmacology, vol.
Interestingly, lipin 1 (LPIN1) was recognized to be the member of both downregulated transcription-regulating GO (regulation of transcription, DNA-dependent) and downregulated metabolic pathways.
(15) It has been shown that HIF-mediated stimulation of lipin 1 expression causes triglyceride accumulation.
Lipin 1 is an inducible amplifier of the hepatic PGC-1 alpha/PPARalpha regulatory pathway.
Chen et al., "Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway," Cell Metabolism, vol.
LPIN1 (lipin 1) and GAMT (guanidinoacetate N-methyltransferase) expression levels are subjected to p53-dependent increase [144, 145].
The activation of PPAR[alpha] by Wy-14643 resulted in a general increase in lipid metabolism-related genes including several involved in lipid synthesis, such as lipin 1 (LPIN1) and sterol regulatory element binding transcription factor 1 (SREBF1) [28].