As far as we know, lipidization amidst central nervous system neoplasms is an intriguing and poorly understood phenomenon which lacks a convincing explanation.
Sarkar, "Ependymoma with extensive lipidization mimicking adipose tissue: a report of five cases," Pathology and Oncology Research, vol.
Cerebellar liponeurocytoma is a rare neoplasm composed of neurocytic cells with variable degrees of tumor cell lipidization. The initial description of this tumor is attributed to Bechtel et al, (1) who, in 1978, described a "mixed mesenchymal and neuroectodermal tumor of the cerebellum" in a 44-year-old man.
In those areas of lipidization, the tumor nuclei are displaced and compressed to the periphery of the cell, causing the tumor cells to resemble mature adipocytes.
Tumor cells in sebaceous carcinoma may be large with squamoid appearance or show basaloid differentiation with limited lipidization
. In the latter case, the tumor needs to be differentiated from basal cell carcinoma; and in the former case, squamous cell carcinoma with clear cell change is in the differential diagnosis.
KEY WORDS: Feathers; Barbs; Differentiation; Lipidization
Throughout the tumor, there are changes represented by areas of hyalinosis, cystic degeneration, and lipidization
. Microangiomatous clusters of vessels are frequently seen.
The effects of emollients include hydration, barrier repair, cooling, protection and lipidization
. Barrier function is highly dependent on lipids (cholesterol, ceramides and free fatty acids) and the formation of normal or abnormal lamellar bodies.
Histiocytoses, such as benign cephalic histiocytosis and generalized eruptive hisiocytoma, do not show the cellular lipidization
observed in this case.
Microscopically, PXA is characterized by neoplastic astrocytes that show marked nuclear pleomorphism, rare-to-absent mitotic figures, nuclear pseudoinclusions, and variable lipidization
. Immunohistochemically, the cells are positive for glial fibrillary acidic protein (GFAP).