Key words: Alcohol abuse; alcohol use and misuse; alcohol disorder; liver; liver disease; hepatitis; hepatitis B virus; hepatitis C virus;
lipid raftsAlso, if high school instructors are unfamiliar with the concept of
lipid rafts, the activity can be renamed "You Ruptured My Plasma Membrane," with a certain number of hits on coordinates corresponding to target "weak spots" resulting in a win.
2001) A role for
lipid rafts in immune cell signaling.
Background and Significance:
Lipid rafts are cholesterol rich membrane microdomains that bring innate immune receptors like Toll like receptor (TLR) together with signaling molecules like Src family tyrosine kinases to transmit the extracellular events into the cytoplasmic cascade of signaling proteins activation.
2009) Alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of
lipid rafts.
Elevated levels of cholesterol-rich
lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents.
2008)
Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE).
Moreover, cholesterol, a main component of
lipid rafts (Pike 2004), regulates BK channel sensitivity to alcohol.
2]-adrenergic receptors do indeed preassociate in clusters supported by intercellular
lipid rafts known as caveolae.
Dr Eric Freed, principal investigator in molecular biology at the American National Institute of Allergy and Infectious Diseases, told the Wall Street Journal, "It adds another human pathogen to the growing list of viruses that use
lipid rafts.
lipid rafts, have been detected in numerous membrane-related cellular processes, including the initiation of the immune response upon T-cell activation.
1990) where it acts through
lipid rafts (Bari et al.
