Ginsenosides R[b.sub.1], R[b.sub.2], Rc and Rd were identified as pancreatic lipase inhibitors.
Weight gain reduction in mice fed panax ginseng saponin, a pancreatic lipase inhibitor. J.
Xenical, the brand name for orlistat, is the first of a new class of drugs called lipase inhibitors
which prevent the digestion of fat.
It belongs to a class of anti-obesity agents, the lipase inhibitors
, developed for long-term management of obesity and its associated co-morbidities, and it is currently the only drug approved in the United States that alters fat digestion.
We will then show how to maintain optimal intake of these key nutrients while obtaining the benefit of lipase inhibitors.
One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor. Int J Obes Relat Metab Disord.
Another study has been designed to determine if castor oil along with lipase inhibitors GSE and EGCG, in combination with other binders including pectin , clay , and activated charcoal  might be of clinical use.
It is possible to add nonabsorbable lipid to the lumen of the intestine, either as a dietary additive such as olestra or through the inhibition of lipase by a lipase inhibitor such as tetrahydrolipstatin.
Lambert, "Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors
," Journal of Medicinal Chemistry, vol.
Polyphenolic compounds as pancreatic lipase inhibitors
. Planta Med 2015; 81: 771-783, doi: 10.1055/s-0035-1565716.
Bhutani, Pancreatic lipase inhibitors
from natural sources: unexplored potential, Drug Discov.
The lipase inhibitor
tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase.