QTL validation: Previously, we identified a major QTL, qSY-3, for SY by using linkage mapping
(Khan et al., 2016).
Maker Chr P value qFDR RM475 * 2 6.80 x [10.sup.-8] 6.65 x [10.sup.-7] RM263 2 1.58 x [10.sup.-5] 6.18 x [10.sup.-5] RM169 5 2.95 x [10.sup.-6] 1.45 x [10.sup.-5] RM224 11 1.77 x [10.sup.-7] 1.15 x [10.sup.-6] RM19 12 1.28 x [10.sup.-8] 2.51 x [10.sup.-7] * RM475 was also associated with straighthead resistance in linkage mapping
of the [F.sub.2] population derived from Zhe733/R312 .
We performed linkage mapping
to discover genomic loci that are associated with benzene-induced chromosomal damage in reticulocytes using DO mice in the combined 100-ppm exposure groups.
Contrary to linkage mapping
, AA is relatively inefficient in capturing the rare variants [50, 54, 55, 68].
There is no question that microsatellites, because of their high levels of polymorphism and co-dominance, are better markers for linkage mapping
than are AFLPs.
Such subject groups are relatively easy to obtain, giving the candidate gene approach an important advantage over the linkage mapping
approach, which requires the analysis of families with multiple affected members.
Results reported here will provide valuable resources for further studies on genetic diversity, genetic linkage and chromosome linkage mapping
Recently, however, single nucleotide polymorphism (SNP) markers have gained popularity for linkage mapping
, which is a result of the fact that single base changes may be responsible for most sequence variation among individuals and, therefore, are more frequently associated with QTLs (Beuzen et al.
Five hundred SNP markers (average of 27.7 SNPs per chromosome) were used for linkage mapping
. The average frequency difference of individual SNPs and the average PIC value between the KNP (n = 16) and YS (n = 8) populations were 0.790 and 0.368, respectively.
Two approaches are mostly used for genetic mapping: (i) Family-based linkage mapping
(ii) LD-based Association mapping (Mackay and Powell, 2007).
and QTL on chromosome 6 in Hanwoo (Korean Cattle).
vannamei, (2) to demonstrate the usefulness of three randomly selected markers to examine allelic variation in wild and cultured shrimp populations, and trace the pedigree of two families from the selective breeding program developed by the USMSFP, and (3) to determine potential usefulness of these microsatellites for linkage mapping