linkage disequilibrium


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link·age dis·e·qui·lib·ri·um

a state involving two loci in which the probability of a joint gamete is not equal to the product of the probabilities of the constituent genes. The difference between these quantities is the increase of the disequilibrium; there are many causes of the disequilibrium.

linkage disequilibrium

a nonrandom association of two genes on the same chromosome.

link·age dis·e·qui·li·bri·um

(lingk'ăj dis-ē'kwi-lib'rē-ŭm)
A state involving two loci in which the probability of a joint gamete is not equal to the product of the probabilities of the constituent genes. The difference between these quantities is the increase of the disequilibrium; there are many causes of the disequilibrium.

linkage disequilibrium

The occurrence of combination of genes (linkages) in a population more often, or less often, than would be expected from their distance apart in the genome.

linkage disequilibrium

a nonrandom association of alleles at different loci in a population, as is produced when two loci are closely linked and selection operates to keep certain gene combinations together.
References in periodicals archive ?
The association between enzyme markers and habitat presumably arises not because of any direct effects of allozymes on behavior, but through linkage disequilibrium with genes responsible for habitat preference.
Linkage disequilibrium in crosses between Illinois maize strains divergently selected for protein percentage.
Estimating contemporary effective population size on the basis of linkage disequilibrium in the face of migration.
The structure of linkage disequilibrium (see Supplemental Material, Figure S1) and haplotypes (see Supplemental Material, Figure S2) in the 200-kb window centered on rs2325934 were constructed using the imputed genotype data of the discovery sample.
The linkage disequilibrium (LD) measurement (D') was calculated between all pairs of SSR markers in the study;
2003) Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine.
The multi-locus haplotype and diplotype are composed of multiple markers that are in linkage disequilibrium (LD).
11,12) The four single nucleotide polymorphisms (SNPs) in the third intron of the STAT4 gene (rs18889341, rs7574865, rs8179673, and rs10181656) were found to be in tight linkage disequilibrium, and they formed a susceptibility haplotype in various investigations that were replicated in European, North American, Colombian, Korean, Northwestern Chinese Han, Northern Chinese Han, Chinese, Egyptian, and Japanese populations.
They studied the extent of linkage disequilibrium (LD) in the genomes of present-day Europeans inorder to understand why the present-day humans share more genetic variants with Neandertals.
Other recent data suggest that the apparent correlation between AD and GABRA2 may result from a linkage disequilibrium with a not-yet-detected functional variant in the neighboring GABRG1 gene.