linkage disequilibrium


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link·age dis·e·qui·lib·ri·um

a state involving two loci in which the probability of a joint gamete is not equal to the product of the probabilities of the constituent genes. The difference between these quantities is the increase of the disequilibrium; there are many causes of the disequilibrium.
Farlex Partner Medical Dictionary © Farlex 2012

link·age dis·e·qui·li·bri·um

(lingk'ăj dis-ē'kwi-lib'rē-ŭm)
A state involving two loci in which the probability of a joint gamete is not equal to the product of the probabilities of the constituent genes. The difference between these quantities is the increase of the disequilibrium; there are many causes of the disequilibrium.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

linkage disequilibrium

The occurrence of combination of genes (linkages) in a population more often, or less often, than would be expected from their distance apart in the genome.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

linkage disequilibrium

a nonrandom association of alleles at different loci in a population, as is produced when two loci are closely linked and selection operates to keep certain gene combinations together.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
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The structure of linkage disequilibrium (see Supplemental Material, Figure S1) and haplotypes (see Supplemental Material, Figure S2) in the 200-kb window centered on rs2325934 were constructed using the imputed genotype data of the discovery sample.
Keywords: Maize (Zea mays L.); Breeding germplasm; Genetic diversity; Linkage disequilibrium; Simple sequence repeat
Linkage disequilibrium: what history has to tell us.
The Hardy-Weinberg equilibrium (HWE) and genotypic linkage disequilibrium between pairs of microsatellites were tested by Genepop 3.4 (Raymond et al.
The multi-locus haplotype and diplotype are composed of multiple markers that are in linkage disequilibrium (LD).
(11,12) The four single nucleotide polymorphisms (SNPs) in the third intron of the STAT4 gene (rs18889341, rs7574865, rs8179673, and rs10181656) were found to be in tight linkage disequilibrium, and they formed a susceptibility haplotype in various investigations that were replicated in European, North American, Colombian, Korean, Northwestern Chinese Han, Northern Chinese Han, Chinese, Egyptian, and Japanese populations.
Association mapping, based on linkage disequilibrium (LD) is expected to achieve a higher resolution as it exploits historical recombinations and targets multiple alleles at individual loci to detect marker-phenotype associations [19, 20] to identify genomic regions linked to a wider range of phenotypic traits.
LdNe: a program for estimating effective population size from data on linkage disequilibrium. Molecular Ecology 8:753-756.