Highly polymorphic fluorescent STR markers (D7S2420, D7S2459 and D7S2456) were used to perform linkage analysis
for DFNB4 locus.
KEYWORDS: Mutation, Genotyping, Pedigree, Linkage analysis
, Polymerase Chain Reaction, Polyacrylamide Gel Electrophoresis.
The two-point and multipoint linkage analysis
were performed by Merlin software program assuming an autosomal recessive mode of inheritance with complete penetrance and a disease allele frequency of 0.001.
was performed in three patients using four polymorphic micro-satellite markers that span the critical MCKD1 region in the following order: cen-D1S305, D1S153, D1S1595, and D1S2624-tel.
Based on this linkage analysis
, we found that collaboration between teams were one major difference.
Although the linear magnetizing inductance assumption is made to simplify the transformer flux linkage analysis
above, the magnetizing inductance of the saturated transformer is actually nonlinear.
A list of markers used in this linkage analysis
can be found in Supplementary Table 1.
Patent-Product Linkage analysis
of KU's patent portfolio has provided some new insights of competitive strategies of KU.
in these two families identified two different loci, 3q21-22 in HCFP1 and 10q21-22 in HCFP2, indicating genetic heterogeneity for this disorder.
through the MAPMAKER/EXP resulted in linkage of 4 SSR loci on a linkage group on 2A wheat chromosome.
The researchers ran a linkage analysis
of Swedish registries and identified 34,984 adult women with RA and matched them with 300,331 women drawn from the general Swedish population.
Therefore, the aim of our study was to use the robust method of linkage analysis
in a large well-characterized cohort of T1D families to identify gene-loci that predispose to type 1 diabetic complications.