linkage analysis


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link·age a·nal·y·sis

the assessment of the linkage relationship between two loci by the examination of data in pedigrees. The classic concern is with estimating recombination fractions and (because of its elasticity, efficiency, and other optimal properties) the preferred method is maximum likelihood estimation. However, there are other more modern concerns, notably determining the order of loci, testing for additive and interactive properties in the mapping function, and reconciling the pedigree data with evidence from other methods (for example, cytogenetics, in situ hybridization studies, etc.).

linkage analysis

Genetics A gene-hunting technique that traces patterns of heredity in large, high-risk families, in an attempt to locate a disease-causing gene mutation by identifying traits co-inherited with it; the formal study of the association between the inheritance of a condition in a family and a particular chromosomal locus; LA is based on certain ground rules of genetics. See Lod score.
References in periodicals archive ?
This family showing a clear pattern of early onset retinitis pigmentosa was checked through linkage analysis against the known genes by using the STS markers.
Linkage analysis was performed in three patients using four polymorphic micro-satellite markers that span the critical MCKD1 region in the following order: cen-D1S305, D1S153, D1S1595, and D1S2624-tel.
Based on this linkage analysis, we found that collaboration between teams were one major difference.
KEY WORDS: Carriers, Factor IX, Haemophilia B, Linkage Analysis.
We carried out genome scans to identify QTL for shank skin color traits by using a multipoint variance component linkage analysis approach.
Linkage analysis identified the locus at 3q21-22, like the Dutch HCFP1 family4.
The researchers ran a linkage analysis of Swedish registries and identified 34,984 adult women with RA and matched them with 300,331 women drawn from the general Swedish population.
An Utah group conducted a sib-pair linkage analysis in 1998.
But the Court of Criminal Appeal in Edinburgh yesterday ruled that so-called case linkage analysis was a science still in its infancy.
The IBCG1 locus was excluded in an Italian family from South Tyrol; however, results of a genome-wide scan linkage analysis revealed a novel locus on chromosome 2q37 (IBGC2) in this family (7), (8).
The Violent Crime Linkage Analysis System compares different crimes with similarities.