linkage analysis


Also found in: Encyclopedia.

link·age a·nal·y·sis

the assessment of the linkage relationship between two loci by the examination of data in pedigrees. The classic concern is with estimating recombination fractions and (because of its elasticity, efficiency, and other optimal properties) the preferred method is maximum likelihood estimation. However, there are other more modern concerns, notably determining the order of loci, testing for additive and interactive properties in the mapping function, and reconciling the pedigree data with evidence from other methods (for example, cytogenetics, in situ hybridization studies, etc.).

linkage analysis

Genetics A gene-hunting technique that traces patterns of heredity in large, high-risk families, in an attempt to locate a disease-causing gene mutation by identifying traits co-inherited with it; the formal study of the association between the inheritance of a condition in a family and a particular chromosomal locus; LA is based on certain ground rules of genetics. See Lod score.
References in periodicals archive ?
Highly polymorphic fluorescent STR markers (D7S2420, D7S2459 and D7S2456) were used to perform linkage analysis for DFNB4 locus.
KEYWORDS: Mutation, Genotyping, Pedigree, Linkage analysis, Polymerase Chain Reaction, Polyacrylamide Gel Electrophoresis.
The two-point and multipoint linkage analysis were performed by Merlin software program assuming an autosomal recessive mode of inheritance with complete penetrance and a disease allele frequency of 0.001.
Linkage analysis was performed in three patients using four polymorphic micro-satellite markers that span the critical MCKD1 region in the following order: cen-D1S305, D1S153, D1S1595, and D1S2624-tel.
Based on this linkage analysis, we found that collaboration between teams were one major difference.
Although the linear magnetizing inductance assumption is made to simplify the transformer flux linkage analysis above, the magnetizing inductance of the saturated transformer is actually nonlinear.
A list of markers used in this linkage analysis can be found in Supplementary Table 1.
Patent-Product Linkage analysis of KU's patent portfolio has provided some new insights of competitive strategies of KU.
Linkage analysis in these two families identified two different loci, 3q21-22 in HCFP1 and 10q21-22 in HCFP2, indicating genetic heterogeneity for this disorder.
Linkage analysis through the MAPMAKER/EXP resulted in linkage of 4 SSR loci on a linkage group on 2A wheat chromosome.
The researchers ran a linkage analysis of Swedish registries and identified 34,984 adult women with RA and matched them with 300,331 women drawn from the general Swedish population.
Therefore, the aim of our study was to use the robust method of linkage analysis in a large well-characterized cohort of T1D families to identify gene-loci that predispose to type 1 diabetic complications.