lines of Blaschko

lines of Blaschko

(blahs'kō),
a pattern of distribution of skin lesions or pigmentary anomalies; linear on the extremities, S-shaped curves on the abdomen, and V-shaped on the back; thought to result from genetic mosaicism (q.v.) and the interplay of transverse clonal proliferation and longitudinal growth and flexion of the embryo.

lines of Blaschko

Dermatology Alterating stripes of affected and unaffected skin, which are seen in certain skin diseases. Cf Dermatomes.

lines of Blasch·ko

(līnz blas'kō)
A pattern of distribution of skin lesions or pigmentary anomalies; linear on the extremities, S-shaped curves on the abdomen, and V-shaped on the back, thought to result from genetic mosaicism and the interplay of transverse clonal proliferation and longitudinal growth and flexion of the embryo.
References in periodicals archive ?
The lesions start as pink or skin-colored asymptomatic papules in a linear orientation following the lines of Blaschko. Lesions usually evolve over several weeks, and typically resolve in 6-12 months.
Linear and Whorled Nevoid Hypermelanosis (LWNH) It was first described by Kaltar et al [1] in 1988, and is characterised by hyperpigmented macules along the lines of Blaschko without any preceding inflammation or atrophy.
Lichen striatus (LS) is an uncommon linear dermatosis that most commonly affects children aged 4 months to 15 years and is distributed along the lines of Blaschko. Diagnosis is made based on clinical appearance of 2 to 4 mm, flat-topped, lichenoid papules ranging from red color to flesh color that are distributed linearly and may be discrete or confluent [1, 2].
Cutaneous manifestations of IP follow the lines of Blaschko and occur in a chronological sequence of 4 stages, which may temporarily overlap.
Doctors use the lines of Blaschko when diagnosing patients and when carrying out surgery, Dr Shergill added.
This pattern corresponds to the lines of Blaschko. The lesions are typically solitary and unilateral, occurring more frequently on the limbs.
NS can be found anywhere on the body, but the most common location is on the chest and upper limbs, and often the arrangement of NS follows the lines of Blaschko (3).
The lesions of port-wine stain are usually unilateral and segmental and do not follow the lines of Blaschko. The lesions often become dark-red during adolescence and violaceous with advancing age.
Of this group, 28 (0.7%) also had pigmentary anomalies along the lines of Blaschko. He prospectively studied this group to establish a clinical profile.
The term hypomelanosis of Ito is applied to individuals with skin hypopigmentation along the lines of Blaschko.[2,3] However, because of conflicting reports about the frequency of associated extracutaneous abnormalities (mostly of the central nervous, musculoskeletal, and ocular systems) and disagreement over terminology, HI still represents a controversial issue in the medical literature.[2,3]
Majority of the linear lesions follow the lines of Blaschko. The appearance of these conditions is helpful in clinching the diagnosis in various disorders.
Linear psoriasis is a rare clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. The pathogenesis remains unclear, though some have proposed it could be explained by the well-established concept of genetic mosaicism [1].