linear epitope


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linear epitope

A section of a protein, consisting of a sequence of amino acids, to which an antibody can bind. Compare CONFORMATIONAL EPITOPE.
References in periodicals archive ?
The article, entitled "A Monoclonal Immunoglobulin G Antibody Directed against an Immunodominant Linear Epitope on the Ricin A Chain Confers Systemic and Mucosal Immunity to Ricin," is the result of collaborative efforts between the Wadsworth Center of the New York State Department of Health (Albany, NY) and Soligenix.
Because none of the 14 mAbs reacted with the denatured fragments NNDC1 or NT3, we did not obtain hybridoma antibodies raised against the linear epitope located in the region containing amino acids 121-213.
The REVEAL[TM] service offers both comprehensive best consensus epitope prediction and rapid high throughput linear epitope mapping in vitro.
The fourth MAb (6F19C11) reacts with a linear epitope located on heavy chain of IgG1, 2, 4 subclasses.
A key factor in the protocol for isolating peptides resembling the linear epitope in the N[H.
Continuing reports of the successful use of the short peptides produced by phage display or by chemical synthesis in determination of binding sequences of various antibodies are evidence for the utility of small peptides in linear epitope mapping [6-11,14-18].
The epitopes present in these proteins exist as conformational and linear epitopes.
Methods: To estimate the protective effect of different additives on the stability of antibody against conformational epitopes (S3 antibody) and linear epitopes (S7 and S11 antibodies) of rHBsAg, heat shock at 37[degrees]C was performed in liquid and solid phases.
Cloning and sequence analysis of the spike protein gene of porcine epidemic diarrhea virus CH/JL strain and identification of its antigenic region containing linear epitopes.
A large number of web servers are available freely on net for the prediction of linear epitopes of proteins from infecting organisms.
Linear epitopes are formed by a continuous sequence of amino acids, while conformational epitopes depend on the position of the amino acids in the protein's three-dimensional structure, which is determined by the combination of its alpha ([alpha]) helix, folded beta ([beta]) sheet, or [beta] coil structures.
Antibodies directed against linear epitopes (residues 1-22, 10-29, and 57-76) were used to assay fractions for N-terminal proBNP immunoreactivity with the intent of delineating the peptide sequences.

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