linear epitope


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linear epitope

A section of a protein, consisting of a sequence of amino acids, to which an antibody can bind. Compare CONFORMATIONAL EPITOPE.
References in periodicals archive ?
Nasimi et al., "Immunization of mice by a multimeric L2-based linear epitope (17-36) from HPV type 16/18 induced cross reactive neutralizing antibodies," Research in Pharmaceutical Sciences, vol.
In total, 19 residues differed between the genogroup B and C strains, of which 3 were located in a linear epitope: residues 164, 240, and 241 of VP1 (Figure 4) (22-25).
Important properties for predicting B-cell epitopes are flexibility, hydrophilicity, and linear epitope predictions.
The article, entitled "A Monoclonal Immunoglobulin G Antibody Directed against an Immunodominant Linear Epitope on the Ricin A Chain Confers Systemic and Mucosal Immunity to Ricin," is the result of collaborative efforts between the Wadsworth Center of the New York State Department of Health (Albany, NY) and Soligenix.
The fourth MAb (6F19C11) reacts with a linear epitope located on heavy chain of IgG1, 2, 4 subclasses.
Because none of the 14 mAbs reacted with the denatured fragments NNDC1 or NT3, we did not obtain hybridoma antibodies raised against the linear epitope located in the region containing amino acids 121-213.
By expanding this pane, users can specify a sequence for a linear epitope. They can also select whether they want an exact match to the sequence, find it as a substring in another epitope, or find epitopes that are homologous to it at 70%, 80%, or 90% sequence identity.
A key factor in the protocol for isolating peptides resembling the linear epitope in the N[H.sub.2] terminus of PSA was the introduction of sequential panning with two MAbs.
CEP [39], together with DiscoTope (http://www.cbs.dtu.dk/services/DiscoTope/), is the first web server developed to predict both linear and conformational epitopes; it relies on residues solvent accessibility and defines a linear epitope when at least three consecutive residues satisfy the solvent exposure parameter.
After evaluation of the various available methods for determining the locations of the epitopes, we decided to use linear epitope mapping with synthetic overlapping peptides because of the volume of useful information provided and the high spatial resolution of the technique.
The epitopes present in these proteins exist as conformational and linear epitopes. Linear epitopes, the majority one bind specifically to antibodies.
Methods: To estimate the protective effect of different additives on the stability of antibody against conformational epitopes (S3 antibody) and linear epitopes (S7 and S11 antibodies) of rHBsAg, heat shock at 37[degrees]C was performed in liquid and solid phases.

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