linear dose-response

linear dose-response

A consistent increase in biological response as increased quantities of a test substance are administered.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

linear dose-response

Therapeutics A consistent ↑ in biologic response as ↑ quantities of a test substance are administered
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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(2008) is to add a modifier to the current linear dose-response slope factor to address potential nonlinearity.
MarzAA showed linear dose-response PK across the 4.5-30 mug/kg dose range, with a terminal half-life of 3.5 hours.
Editor's Note: The combined data support a role for magnesium in reducing risk of [type II diabetes], with a statistically significant linear dose-response pattern within the reference dose range of dietary intake among Asian and US populations.
If the hypothesis did not hold, we conducted a linear dose-response meta-analysis to test the risk of breast cancer with each additional hour of sleep.
Contrary to the findings of the two PURE analyses, these data showed "strong evidence of a linear dose-response relationship" between sodium intake and blood pressure, such that each reduction of 2.30 g/day of sodium was significantly linked with a reduction of 3.82 mm Hg in systolic blood pressure, as well as a direct correlation between increasing blood pressure and increasing CV mortality Extrapolating from these data, "we found that 1.65 million deaths from CV causes worldwide in 2010 were attributable to sodium consumption above the reference level" of 2 g/ day.
This adherence to linear dose-response ideology produces confusion in the face of conflicting results.
The linear dose-response relationship showed the risk of stroke decreased by 32% (0.68 [0.56-0.82]) and 11% (0.89 [0.81-0.98]) for every 200 grams per day increment in fruit consumption (P for nonlinearity=0.77) and vegetable consumption (P for nonlinearity=0.62), respectively.
Cadmium, diesel, lead, manganese, mercury, methylene chloride, and nickel showed roughly linear dose-response relationships between concentration and odds ratio of ASD.
"Like most other scientists studying BPA,' we do not see a straightforward linear dose-response relationship," she said.
The findings suggest that "if the association between stroke and pollution is causal and a linear dose-response occurs, a 2-mcg/[m.sup.3] reduction in mean [PM.sub.2.5] levels (approximately 20%) during this time period might have averted approximately 6,100 of the 184,000 stroke hospitalizations observed in the U.S.
Although the observed relative risk of stroke was modest, the findings suggest that "if the association between stroke and pollution is causal and a linear dose-response occurs, a 2-mi-crogram/m3 reduction in mean PM2 5 levels (approximately 20%) during this time period might have averted approximately 6,100 of the 184,000 stroke hospitalizations observed in the U.S.

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