(2008) is to add a modifier to the current linear dose-response
slope factor to address potential nonlinearity.
For arsenic, lead, and cadmium there was a linear dose-response
relation with cardiovascular outcomes.
MarzAA showed linear dose-response
PK across the 4.5-30 mug/kg dose range, with a terminal half-life of 3.5 hours.
Editor's Note: The combined data support a role for magnesium in reducing risk of [type II diabetes], with a statistically significant linear dose-response
pattern within the reference dose range of dietary intake among Asian and US populations.
If the hypothesis did not hold, we conducted a linear dose-response
meta-analysis to test the risk of breast cancer with each additional hour of sleep.
Contrary to the findings of the two PURE analyses, these data showed "strong evidence of a linear dose-response
relationship" between sodium intake and blood pressure, such that each reduction of 2.30 g/day of sodium was significantly linked with a reduction of 3.82 mm Hg in systolic blood pressure, as well as a direct correlation between increasing blood pressure and increasing CV mortality Extrapolating from these data, "we found that 1.65 million deaths from CV causes worldwide in 2010 were attributable to sodium consumption above the reference level" of 2 g/ day.
This adherence to linear dose-response
ideology produces confusion in the face of conflicting results.
The linear dose-response
relationship showed the risk of stroke decreased by 32% (0.68 [0.56-0.82]) and 11% (0.89 [0.81-0.98]) for every 200 grams per day increment in fruit consumption (P for nonlinearity=0.77) and vegetable consumption (P for nonlinearity=0.62), respectively.
Cadmium, diesel, lead, manganese, mercury, methylene chloride, and nickel showed roughly linear dose-response
relationships between concentration and odds ratio of ASD.
"Like most other scientists studying BPA,' we do not see a straightforward linear dose-response
relationship," she said.
The findings suggest that "if the association between stroke and pollution is causal and a linear dose-response
occurs, a 2-mcg/[m.sup.3] reduction in mean [PM.sub.2.5] levels (approximately 20%) during this time period might have averted approximately 6,100 of the 184,000 stroke hospitalizations observed in the U.S.
Although the observed relative risk of stroke was modest, the findings suggest that "if the association between stroke and pollution is causal and a linear dose-response
occurs, a 2-mi-crogram/m3 reduction in mean PM2 5 levels (approximately 20%) during this time period might have averted approximately 6,100 of the 184,000 stroke hospitalizations observed in the U.S.