linear IgA dermatosis
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linear IgA dermatosisAn autoimmune, subepidermal vesiculobullous disease that may be idiopathic, drug-induced (especially by vancomycin) or triggered by a preceding infection or cancer. It is similar to bullous pemphigoid dermatitis herpetiformis, associated with HLA-B8 and gluten sensitivity and linear deposition of IgA along the basement membrane, and often has circulating IgA antibodies against part of the 180-kD bullous pemphigoid antigen BPAg2. Remission occurs in 64% of children within 2 years of onset (average age of child onset, 4 years) and 48% of adults within 5–6 years of onset (average age of adult onset, 52).
Prolonged prodromal itching, transient pruritus or burning before lesions appear; ocular manifestations are characterised by pain, grittiness or discharge. Bullae may be chronic or appear acutely, as seen in drug-induced disease. Lesions in children are typically located over the lower abdomen and anogenital region; in adults, the lesions overlie the trunk and limbs.
Linear IgA deposition along the basement membrane by direct immunofluorescence.
Leave bullae intact; cover ruptured lesions and erosions with sterile dressings.
pl dermatoses; any skin disorder, especially one not characterized by inflammation.
a disease of unknown etiology which occurs in pigs, mainly the white varieties; there is nonpruritic, acute erythema over large areas of the body and spontaneous recovery occurs in a matter of days.
one involving severe desquamation; includes drug reaction, contact hypersensitivity, autoimmune diseases, cutaneous lymphomas and parapsoriasis.
generic dog food dermatosis
see generic pet food.
growth hormone-responsive dermatosis
see growth hormone-responsive dermatosis.
hereditary lupoid dermatosis
a scaling and crusting skin disease seen from a young age in German shorthaired pointers.
infantile pustular dermatosis
pustules, depression and anorexia in neonatal puppies; the etiology is unknown.
skin diseases which are evident clinically, but the histopathology is consistent with normal skin.
linear IgA dermatosis
a rare, immune-mediated skin disease of Dachshunds in which immunoglobulin A is deposited at the basement membrane zone. There are pustules, with alopecia, hyperpigmentation, scaling and crusting.
linear preputial dermatosis
a narrow line of hyperpigmentation along the midline between the prepuce and scrotum is considered a marker for testicular neoplasia in dogs.
see seborrheic dermatitis.
subcorneal pustular dermatosis
a very rare skin disorder of dogs in which short-lived, sterile, superficial pustules form, particularly on the head and trunk. Pruritus is variable. The cause is unknown.
see ulcerative dermatosis.
an inherited skin disease of Landrace pigs. Young piglets may be affected at birth or develop at an early age an erythematous, papular dermatitis, mainly on the ventral abdomen and medial thighs. There is also erythema and edema of the coronary bands and subsequent deformities of the foot. Pneumonia develops before death.
a breed-related form occurs in Siberian huskies and several other Artic breeds, and a dermatosis can occur in puppies of any breed if their diet is deficient in zinc or absorption is impaired by excessive supplementation of calcium. There is scaling and crusting, especially over pressure points and footpads. See also parakeratosis for a similar disease in pigs and a familial one in cattle.