lindane


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Related to lindane: permethrin

lindane

 [lin´dān]
the gamma isomer of benzene hexachloride, used as a topical treatment for lice and scabies.

lindane

Hexit Lotion (CA), Hexit Shampoo 1 (CA), PMS-Lindane LOT 1 (CA), PMS-Lindane SHP 1 (CA)′

Pharmacologic class: Chlorinated hydrocarbon

Therapeutic class: Scabicide, pediculocide

Pregnancy risk category C

FDA Box Warning

• Use only in patients who can't tolerate or have failed first-line treatment with safer drugs.

• Seizures and deaths have occurred with repeat or prolonged application, and in rare cases after a single application used as directed. Use cautiously in infants, children, elderly patients, persons with other skin conditions, and in those weighing less than 110 lb (50 kg).

• Drug is contraindicated in premature infants and patients with uncontrolled seizure disorders.

• Instruct patient about proper drug use, amount to apply, how long to leave it on, and importance of avoiding retreatment.

Action

Absorbed through parasitic ova and arthropods, which stimulates parasitic nervous system and results in seizures and death of parasite

Availability

Lotion: 1%

Shampoo: 1%

Indications and dosages

Secondary treatment of scabies

Adults and children: Apply enough lotion on dry skin to cover entire surface from neck down. Rub in well, and leave in place 12 hours. Then wash skin thoroughly.

Secondary treatment of Pediculosis capitis (head lice) or Pediculosis pubis (pubic lice)

Adults and children: Apply enough shampoo to dry hair (1 oz or less for short hair, 1½ oz for medium length hair, up to 2 oz for long hair) to thoroughly wet hair and skin or scalp of affected and surrounding hairy areas. Leave in place 12 hours. Then wash hair thoroughly.

Contraindications

• Hypersensitivity to drug or its components
• Seizure disorder
• Crusted (Norwegian) scabies and other conditions that may increase systemic drug absorption
• Premature neonates

Precautions

Use cautiously in:
• conditions that increase seizure risk (such as history of seizures, head injury, AIDS)
• skin conditions
• concurrent use of skin creams, oils, or ointments
• patients weighing less than 50 kg (110 lb)
• elderly patients
• breastfeeding patients
• infants or children.

Administration

• To apply, wear gloves made of nitrile, latex with neoprene, or sheer vinyl.
• Before applying lindane shampoo, use regular shampoo without conditioner; rinse and dry hair completely. Wait 1 hour before using lindane shampoo.
• Don't use lindane lotion or shampoo with other lotions, creams, or oils.
• Thoroughly wash skin after lotion has been in place for 12 hours.

Adverse reactions

CNS: dizziness, seizures, headache, anxiety, paresthesia

EENT: irritation of eyes, nose, and throat (from vapor inhalation)

GI: nausea and vomiting (from vapor inhalation)

Hematologic: aplastic anemia (with prolonged use)

Skin: dermatitis, urticaria, pruritus, alopecia

Other: pain

Interactions

Drug-drug.Drugs that lower seizure threshold, antidepressants: increased seizure activity

Patient monitoring

• Monitor drug efficacy.

Patient teaching

Emphasize that drug is for external use only, and that ingesting even small amounts can be fatal.
• If drug will be applied by another person, tell patient that this person must wear gloves made of nitrile, latex with neoprene, or sheer vinyl.
• Instruct patient using lindane lotion to wash, rinse, and dry skin well before applying lindane if skin has cream, lotion, ointment, or oil on it. If he takes a warm bath or shower before applying lindane, instruct him to let skin dry and cool down. Then tell him to apply lindane to dry skin, rub in well, leave on skin for 8 to 12 hours, and then remove it by washing thoroughly.
• Instruct patient using lindane shampoo to apply enough shampoo to dry hair to thoroughly wet the hair and skin or scalp of affected and surrounding hairy areas, and then rub shampoo thoroughly into hair and skin or scalp and let it sit for 4 minutes. Then tell him to add just enough water to work up a good lather, then rinse thoroughly and dry hair with clean towel. When hair is completely dry, instruct him to comb it with a fine-toothed comb to remove any remaining nits or nit shells. Tell him not to use shampoo in combination with oils, lotions, or creams.
• To avoid reinfestation, instruct patient to launder all recently worn or used clothing, bed linens, and towels in hot water.
• Caution patient to avoid contact with eyes when applying lotion or shampoo.
• Tell patient with scabies that sexual contacts and other close personal contacts should be examined and, if necessary, treated.
• Advise female patient to inform prescriber if she plans to breastfeed.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

lindane

/lin·dane/ (lin´dān) the gamma isomer of benzene hexachloride, used as a topical pediculicide and scabicide.

lindane

(lĭn′dān)
n.
An isomer of the chlorocarbon C6H6Cl6, obtained as a white crystalline powder and having a musty odor. A potent pesticide, it has been banned from agricultural use in several countries including the United States, but is used topically in the treatment of scabies and pediculosis. Also called gamma benzene hexachloride.

lindane

[lin′dān]
a gamma-benzene hexachloride.
indications It is prescribed in the treatment of pediculosis and scabies.
contraindications It is not usually given to infants or pregnant women and is not applied to the face. Known hypersensitivity to this drug prohibits its use.
adverse effects Among the most serious adverse effects are neurological damage and aplastic anemia. Topical administration may result in irritation of eyes, skin, and mucosa.

lindane

Toxicology The γ-isomer of benzene hexachloride; a carcinogenic, lipid-soluble insecticide used topically to control lice and scabies, and occasionally for suicide; 20-30 g produce serious toxicity or death Clinical Onset is similar to DDT poisoning–tremors, ataxia, violent tonic-clonic convulsions, pulmonary edema and vascular collapse of neurogenic origin; massive hepatic necrosis ensues, accompanied by hyaline degeneration of renal tubules, aplastic anemia

Lindane

A benzene compound that is used to kill body and pubic lice. Lindane works by being absorbed into the louse's central nervous system, causing seizures and death.
Mentioned in: Lice Infestation

lindane

(lin´dān),
n g-benzene hexachloride prescribed in the treatment of pediculosis and scabies.

lindane

the gamma isomer of benzene hexachloride used as a topical pediculicide and scabicide. Carries the same toxicity risks as all chlorinated hydrocarbons. Called also γ-HCH, γ-BHC, gamma benzene hexachloride.
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The GC-MS study of the degradation of lindane by bacterial and fungal strain was carried out with the hexane extracts.
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Company officials say that previously the only treatment to control lice has been to soak the child's head with a pediculicide containing a toxic insect-killing chemical like malathion, lindane, permethrin or pyrethrins.
Among other things, the agency was instrumental in helping Mexico phase out the use of the deadly toxic pesticides DDT and lindane, and assisted in securing a presidential declaration to designate the Cozumel Reefs as a protected area.
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The two companies, which control nearly 100% of India's soft-drink business, have received a setback after a well-publicized test conducted by a Delhi-based environmental group revealed that their products contain large doses of lindane, DDT, chlorpyrifos, malathion and other toxins.
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I'm naturally interested to find out whether certain chemicals such as lindane and DDT which are no longer used in agriculture can still be traced in our blood.
Since then, signatory nations have added four more POPs to the list: the pesticides lindane (also known as gamma-hexachlorocyl-cohexane) and chlordecone (also known as kepone); hexabromobiphenyl, a polybrominated flame retardant; and polycyclic-aromatic hydrocarbons (PAHs), which are combustion byproducts.
Lindane also is category B but historically has been avoided in pregnancy.