Imfinzi is also being tested following concurrent chemoradiation therapy in limited-stage
SCLC in the Phase III ADRIATIC trial.
The drug is also being assessed in limited-stage
SCLC after concurrent chemoradiation therapy in a phase three trial, called ADRIATIC.
Astra also is testing Imfinzi for limited-stage
small cell lung cancer treatment in the Phase III Adriatic trial.
Randomized comparison of ABVD chemotherapy with a strategy that includes radiation therapy in patients with limited-stage
Hodgkin's lymphoma: National Cancer Institute of Canada Clinical Trials Group and the Eastern Cooperative Oncology Group.
72%) survival, but on longer follow-up of this trial revealed no significant difference in progression-free survival or OS., Patients with nonbulky limited-stage
DLBCL, treatment with abbreviated chemotherapy (R-CHOP x 3) plus involved-field radiotherapy (30-36 Gy) rather than extended chemotherapy (R-CHOP x 6-8) alone is the preferred modality of treatment.
Patients with limited-stage
FLs treated with radiation therapy, usually external beam radiation therapy, have shown a long disease-free survival following therapy, with an overall survival rate of 60% to 80% at 10 years.
Patients with SCC tend to progress quickly and develop metastases , and their prognosis is poor even with limited-stage
Thoracic radiotherapy combined with chemotherapy improves survival in patients with limited-stage
small cell lung cancer [17, 18].
Chuang et al., "Doxorubicin Based Chemotherapy and Radiation Therapy Produces Favorable Outcomes in Limited-Stage
Plasmablastic Lymphoma: A Single-Institution Review," Clinical Lymphoma, Myeloma and Leukemia, vol.
Raderer et al., "Helicobacter pylori eradication as exclusive treatment for limited-stage
gastric diffuse large B-cell lymphoma: results of a multicenter phase 2 trial," Blood, vol.
Long term safety concerns which emerged with the use of radiotherapy led to use of chemotherapy alone for treatment of early-stage favorable risk HL resulting in more or less similar outcome as shown with CMT.12,13 Recent trials for patients with limited-stage
HL have demonstrated that treatment with chemotherapy plus involved-field radiation therapy (IFRT) and chemotherapy alone with Doxorubicin (Adriamycin), Bleomycin, Vinblastine, and Dacarbazine (ABVD) may both be acceptable options for these patients.5,14 Some studies have highlighted the role of interim PET/CT to guide treatment; however, this approach may not be applicable everywhere because the availability of this imaging modality is still sparse in many countries.15,16
It can be classified into two stages: limited-stage
small cell lung cancer and extensive-stage small cell lung cancer.