limb-girdle muscular dystrophy


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limb-·gir·dle mus·cu·lar dys·tro·phy

[MIM*253600]
a group of muscular dystrophies, probably heterogeneous in nature. Onset usually in childhood or early adulthood and both sexes affected. Characterized by weakness and wasting, usually symmetric, of the pelvic girdle muscles, the shoulder girdle muscles, or both, but not the facial muscles. Muscle pseudohypertrophy, heart involvement, and mental retardation are absent. Autosomal dominant and recessive inheritance have been described.
Farlex Partner Medical Dictionary © Farlex 2012

limb-girdle muscular dystrophy

n.
Any of several forms of muscular dystrophy that chiefly affect the skeletal muscles of the shoulder and pelvic girdles, with symptoms beginning at any age.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

limb-gir·dle mus·cu·lar dys·tro·phy

(lim'gĭr'dĕl mŭs'kyū-lăr dis'trŏ-fē)
One of the less well-defined types of this disorder, it is characterized by weakness and wasting, usually symmetric, of the pelvic girdle muscles, the shoulder girdle muscles, or both, but not the facial muscles. Muscle pseudohypertrophy, heart involvement, and mental retardation are absent. Variable inheritance.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Limb-girdle muscular dystrophy (LGMD)

An autosomal recessive form of muscular dystrophy that appears anywhere from late childhood to middle age and is characterized by progressive muscular weakness beginning either in the shoulder or pelvic girdle; the disease usually progresses slowly with cardio-pulmonary complications in the later stages
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Leyden,

Ernst V. von, German physician, 1832-1910.
Charcot-Leyden crystals - see under Charcot
Leyden ataxia - Synonym(s): Westphal-Leyden syndrome
Leyden crystals - Synonym(s): Charcot-Leyden crystals
Leyden disease
Leyden-Möbius muscular dystrophy - Synonym(s): limb-girdle muscular dystrophy
Leyden neuritis - fatty degeneration of the fibers of the affected nerve.
Westphal-Leyden syndrome - see under Westphal

Möbius,

Paul J., German physician, 1853-1907.
Leyden-Möbius muscular dystrophy - Synonym(s): limb-girdle muscular dystrophy
Möbius sign - impairment of ocular convergence in Graves disease.
Möbius I syndrome - moderate migraine accompanied by extraocular palsy. Synonym(s): occasional oculomotor paralysis; ophthalmoplegic migraine
Möbius II syndrome - a developmental bilateral facial paralysis usualy associated with oculomotor or other neurological disorders.Synonym(s): congenital facial diplegia; developmental bilateral facial paralysis
Medical Eponyms © Farlex 2012
References in periodicals archive ?
There are at least a dozen different forms of LGMD, and they're classified by the genetic flaws that appear to cause them (see "Known Forms of Limb-Girdle Muscular Dystrophy").
Gradually, the muscles become weak enough that people experience the symptoms of limb-girdle muscular dystrophy. Because LGMD is progressive, the muscles continue to get weaker throughout the person's lifetime.
* MUSCLES AND MUSCLE CELLS IN LIMB-GIRDLE MUSCULAR DYSTROPHY
The onset of limb-girdle muscular dystrophy is usually in late childhood or early adulthood, although in rare instances it may show first symptoms in older adults.
R25G mutation in exon 1 of LMNA gene is associated with dilated cardiomyopathy and limb-girdle muscular dystrophy 1B.
As limb-girdle muscular dystrophy was taken into the clinical consideration first, the targeted NGS was performed for the further diagnosis.
A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B.
Dysferlin aggregation in limb-girdle muscular dystrophy type 2B/Miyoshi myopathy necessitates mutational screen for diagnosis [corrected].