limb perfusion


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limb perfusion

Oncology The delivering of chemotherapy directly to an arm or leg, in which the flow of blood through the limb is temporarily stopped with a tourniquet, and anticancer drugs are injected IV

limb perfusion

A method for concentrating a dose of chemotherapy in an arm or leg affected by cancer. Large blood vessels near the tumor are cannulated; the limb is wrapped in a tourniquet, and chemotherapy is circulated into the limb. Isolated limb perfusion has been used to treat melanomas or sarcomas. Synonym: isolated limb perfusion
See also: perfusion
References in periodicals archive ?
Hypothermic perfusions are adopted for isolated organ and limb perfusions with the aim to promote organ preservation and facilitate reimplantation (Smith et al., 1985; Domingo-Pech et al., 1991; Guarrera et al., 2004; Constantinescu et al., 2011; MUller et al., 2013).
In contrast, lactate levels were (constantly) elevated in the venous perfusate in porcine isolated limb perfusions (up to 105 mg/dl (Wagner et al., 2003), mean maximum value 19.59 mmol/l (Constantinescu et al., 2011)) likely due to the higher metabolic demands of a greater amount of included soft tissues.
Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999-2009).
How to perform intravenous regional limb perfusion using amikacin and DMSO.
The limb perfusion evaluated by laser Doppler analysis demonstrated that MVs significantly enhanced perfusion in respect to control [68].
Radiation, hyperthermic limb perfusion chemotherapy, and chemotherapy are used in the treatment of malignant spiradenomas, the mainstay of treatment of spiradenomas and malignant spiradenomas is surgical removal, Mohs micrographic surgery offers the most conservative treatment choice Multiple spiradenomas, such as those found in Brooke-Spiegler syndrome can be treated with a high-energy continuous wave carbon dioxide laser after debulking with bipolar scissors.
Traditionally, the patient has been faced with either amputation or major surgery, known as isolated limb perfusion (ILP).
Cell-based regenerative therapies aiming at neovascularization and improved limb perfusion have been proposed as novel treatment strategies.