Hypothermic perfusions are adopted for isolated organ and limb perfusions with the aim to promote organ preservation and facilitate reimplantation (Smith et al., 1985; Domingo-Pech et al., 1991; Guarrera et al., 2004; Constantinescu et al., 2011; MUller et al., 2013).
In contrast, lactate levels were (constantly) elevated in the venous perfusate in porcine isolated limb perfusions (up to 105 mg/dl (Wagner et al., 2003), mean maximum value 19.59 mmol/l (Constantinescu et al., 2011)) likely due to the higher metabolic demands of a greater amount of included soft tissues.
Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999-2009).
How to perform intravenous regional limb perfusion using amikacin and DMSO.
The limb perfusion
evaluated by laser Doppler analysis demonstrated that MVs significantly enhanced perfusion in respect to control .
Radiation, hyperthermic limb perfusion
chemotherapy, and chemotherapy are used in the treatment of malignant spiradenomas, the mainstay of treatment of spiradenomas and malignant spiradenomas is surgical removal, Mohs micrographic surgery offers the most conservative treatment choice Multiple spiradenomas, such as those found in Brooke-Spiegler syndrome can be treated with a high-energy continuous wave carbon dioxide laser after debulking with bipolar scissors.
Traditionally, the patient has been faced with either amputation or major surgery, known as isolated limb perfusion
Cell-based regenerative therapies aiming at neovascularization and improved limb perfusion
have been proposed as novel treatment strategies.